1,3-Dioxolane-4-ethanol, 2,2-dimethyl-, 4-methylbenzenesulfonate

Base Information

• Chemical Name: 1,3-Dioxolane-4-ethanol, 2,2-dimethyl-, 4-methylbenzenesulfonate
• CAS No.: 55559-75-6
• Molecular Formula: C14H20O5S
• Molecular Weight: 300.376
• Mol file: 55559-75-6.mol

Synonyms:1,3-Dioxolane-4-ethanol,2,2-dimethyl-,4-methylbenzenesulfonate;

Chemical Property of 1,3-Dioxolane-4-ethanol, 2,2-dimethyl-, 4-methylbenzenesulfonate

Chemical Property:

• PSA: 101.44000
• LogP: 2.84280

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Dioxolane-4-ethanol, 2,2-dimethyl-, 4-methylbenzenesulfonate

There total 6 articles about 1,3-Dioxolane-4-ethanol, 2,2-dimethyl-, 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolane (5754-34-7) + p-toluenesulfonyl chloride (98-59-9) → 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl 4-methylbenzenesulfonate (55559-75-6)

Guidance literature:

With dmap; triethylamine; In dichloromethane; 1) 0-5 deg C, 3.5 h; 2) rt, 6 h;

DOI:10.1021/jo951319i

Reference yield:

4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolane (5754-34-7) + p-toluenesulfonylanhydride (4124-41-8) → 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl 4-methylbenzenesulfonate (55559-75-6)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃;

Reference yield:

D,L-1,2,4-butanetriol (3068-00-6,6810-31-7) + p-toluenesulfonyl chloride (98-59-9) + acetone (67-64-1) → toluene-4-sulfonic acid 2,2-dimethyl-[1,3]dioxan-4-ylmethyl ester + 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl 4-methylbenzenesulfonate (55559-75-6)

Guidance literature:

D,L-1,2,4-butanetriol; acetone; With toluene-4-sulfonic acid; at 20 ℃; for 24h;

p-toluenesulfonyl chloride; With triethylamine; In dichloromethane; at 0 ℃; for 22h; Further stages. Title compound not separated from byproducts.;

DOI:10.1021/ja020816v

upstream raw materials:

4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolane

p-toluenesulfonyl chloride

D,L-1,2,4-butanetriol

acetone

Downstream raw materials:

N,N-dibenzyl-2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethanamine

(+/-)-1,2-O-isopropylidene-4-O-(2-chloro-4-nitrophenyl)-1,2,4-butanetriol

(+/-)-1,2-O-isopropylydene-4-(4-nitrophenyloxy)-1,2-butanediol

2,2-dimethyl-4-vinyl-1,3-dioxolane