(+/-)-1,2-O-isopropylydene-4-(4-nitrophenyloxy)-1,2-butanediol

Base Information

• Chemical Name: (+/-)-1,2-O-isopropylydene-4-(4-nitrophenyloxy)-1,2-butanediol
• CAS No.: 796853-59-3
• Molecular Formula: C₁₃H₁₇NO₅
• Molecular Weight: 267.282
• Mol file: 796853-59-3.mol

Synonyms:(+/-)-1,2-O-isopropylydene-4-(4-nitrophenyloxy)-1,2-butanediol

Chemical Property of (+/-)-1,2-O-isopropylydene-4-(4-nitrophenyloxy)-1,2-butanediol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-1,2-O-isopropylydene-4-(4-nitrophenyloxy)-1,2-butanediol

There total 1 articles about (+/-)-1,2-O-isopropylydene-4-(4-nitrophenyloxy)-1,2-butanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl 4-methylbenzenesulfonate (55559-75-6) + 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → (+/-)-1,2-O-isopropylydene-4-(4-nitrophenyloxy)-1,2-butanediol (796853-59-3)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In acetone; for 18h; Heating;

DOI:10.1016/j.tetasy.2004.07.059

Reference yield: 92.0%

(+/-)-1,2-O-isopropylydene-4-(4-nitrophenyloxy)-1,2-butanediol (796853-59-3) → (+/-)-4-(4-nitrophenyloxy)-1,2-butanediol (40742-23-2)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 18h;

DOI:10.1016/j.tetasy.2004.07.059

Reference yield:

(+/-)-1,2-O-isopropylydene-4-(4-nitrophenyloxy)-1,2-butanediol (796853-59-3) → (+/-)-4-(4-nitrophenyloxy)-2-hydroxybut-1-yl cis-9-octadecenoate

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / hydrochloric acid / methanol / 18 h / 20 °C

2: 60 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂; dimethylformamide / 18 h / 20 °C

With hydrogenchloride; dmap; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tetasy.2004.07.059

upstream raw materials:

2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl 4-methylbenzenesulfonate

4-nitro-phenol

Downstream raw materials:

(+/-)-4-(4-nitrophenyloxy)-1,2-butanediol

(+/-)-4-(p-nitrophenoxy)-1-acetoxy-2-hydroxybutane