Methyl 1,2,3,4-tetrahydroacridine-9-carboxylate

Base Information

Chemical Name:Methyl 1,2,3,4-tetrahydroacridine-9-carboxylate
CAS No.:55618-86-5
Molecular Formula:C15H15NO2
Molecular Weight:241.29
Hs Code.:
European Community (EC) Number:660-699-9
ChEMBL ID:CHEMBL1814407

Synonyms:methyl 1,2,3,4-tetrahydroacridine-9-carboxylate;55618-86-5;Enamine_001189;Oprea1_704390;CHEMBL1814407;HMS1397G01;MFCD00435229;STL477111;AKOS000348667;BS-50626;CS-0326991;E84403;methyl 1,2,3,4-tetrahydro-9-acridinecarboxylate;methyl1,2,3,4-tetrahydroacridine-9-carboxylate;SR-01000028788;SR-01000028788-1;Z19690430

Suppliers and Price of Methyl 1,2,3,4-tetrahydroacridine-9-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Methyl 1,2,3,4-tetrahydroacridine-9-carboxylate

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:241.110278721
Heavy Atom Count:18
Complexity:318

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1=C2CCCCC2=NC3=CC=CC=C31

Technology Process of Methyl 1,2,3,4-tetrahydroacridine-9-carboxylate

There total 5 articles about Methyl 1,2,3,4-tetrahydroacridine-9-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 38186-54-8
1,2,3,4-tetrahydro-9-acridinecarboxylic acid

: 55618-86-5
methyl-[(1,2,3,4-tetrahydro-9-yl)acridine]carboxylate

Guidance literature:: In methanol; at 20 ℃; for 2h;
DOI:10.1021/jm049510k

Reference yield: 72.0%

: 38186-54-8
1,2,3,4-tetrahydro-9-acridinecarboxylic acid

: 74-88-4
methyl iodide

: 55618-86-5
methyl-[(1,2,3,4-tetrahydro-9-yl)acridine]carboxylate

Guidance literature:: With potassium carbonate; In acetone; for 5h; Reflux;
DOI:10.1016/j.bmc.2011.04.039

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 55618-86-5
methyl-[(1,2,3,4-tetrahydro-9-yl)acridine]carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / 0.5 h / Reflux

1.2: 20 h / Reflux

2.1: potassium carbonate / acetone / 5 h / Reflux

With potassium carbonate; potassium hydroxide; In acetone; 1.1: Pfitzinger reaction / 1.2: Pfitzinger reaction;
DOI:10.1016/j.bmc.2011.04.039