1H-1,5-Benzodiazepine, 2,3-dihydro-2-methyl-2,4-diphenyl-

Base Information

• Chemical Name: 1H-1,5-Benzodiazepine, 2,3-dihydro-2-methyl-2,4-diphenyl-
• CAS No.: 55626-14-7
• Molecular Formula: C22H20N2
• Molecular Weight: 312.414
• DSSTox Substance ID: DTXSID20396391
• Nikkaji Number: J1.097.936F
• ChEMBL ID: CHEMBL1169821
• Mol file: 55626-14-7.mol

Synonyms:2-methyl-2,4-diphenyl-2,3-dihydro-1H-1,5-benzodiazepine;55626-14-7;1H-1,5-Benzodiazepine, 2,3-dihydro-2-methyl-2,4-diphenyl-;CDS1_003008;ChemDivAM_001043;ChemDiv1_022784;Oprea1_789958;MLS001047227;DivK1c_004048;CHEMBL1169821;SCHEMBL15989564;HMS651L14;DTXSID20396391;HMS2808M08;STK256907;AKOS000422945;AKOS016038512;SMR000427563;EU-0073410;SR-01000450329;SR-01000450329-1;2,3-Dihydro-2-methyl-2,4-diphenyl-1H-1,5-benzodiazepine;2-Methyl-2,4-diphenyl-2,3-dihydro-1H-benzo[b][1,4]diazepine

Chemical Property of 1H-1,5-Benzodiazepine, 2,3-dihydro-2-methyl-2,4-diphenyl-

Chemical Property:

• XLogP3: 4.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 312.162648646
• Heavy Atom Count: 24
• Complexity: 445

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CC(=NC2=CC=CC=C2N1)C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of 1H-1,5-Benzodiazepine, 2,3-dihydro-2-methyl-2,4-diphenyl-

There total 10 articles about 1H-1,5-Benzodiazepine, 2,3-dihydro-2-methyl-2,4-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

acetophenone (98-86-2) + 1,2-diamino-benzene (95-54-5) → 2-methyl-2,4-diphenyl-2,3-dihydro-1H-1,5-benzo[b][1,4]diazepine (55626-14-7)

Guidance literature:

With ytterbium(III) triflate; at 20 ℃; for 4h;

DOI:10.1016/S0040-4039(01)00413-0

Reference yield: 98.0%

→ 2-methyl-2,4-diphenyl-2,3-dihydro-1H-1,5-benzo[b][1,4]diazepine (55626-14-7)

Guidance literature:

With geissois pruinosa supported over Si₀₂; at 50 ℃; for 1h;

Reference yield: 96.0%

phenylacetylene (536-74-3) + 1,2-diamino-benzene (95-54-5) → 2-methyl-2,4-diphenyl-2,3-dihydro-1H-1,5-benzo[b][1,4]diazepine (55626-14-7)

Guidance literature:

With C₁₄H₃₈AuB₁₀BrP₂; In methanol; at 20 ℃; for 3h; Reagent/catalyst; Solvent; Time;

upstream raw materials:

dypnone

o-phenylenediamine hydrochloride

acetophenone

1,2-diamino-benzene

Downstream raw materials:

1,2-diamino-benzene

acetophenone 2,4-dinitrophenylhydrazone

2,3,4,5-tetrahydro-2-methyl-2,4-diphenyl-1H-benzo[b][1,4]diazepine

2-methyl-2,4-bis(4-nitrophenyl)-2,3-dihydro-1H-benzo[b][1,4]diazepine