3-bromo-2-chloroaniline

Base Information

• Chemical Name: 3-bromo-2-chloroaniline
• CAS No.: 56131-46-5
• Molecular Formula: C6H5BrClN
• Molecular Weight: 206.469
• Hs Code.: 2921420090
• Mol file: 56131-46-5.mol

Synonyms:

Chemical Property of 3-bromo-2-chloroaniline

Chemical Property:

• Melting Point: 31-33 °C
• Boiling Point: 267.1±20.0 °C(Predicted)
• PKA: 1.58±0.10(Predicted)
• PSA: 26.02000
• Density: 1.722±0.06 g/cm3(Predicted)
• LogP: 3.26590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-2-chloroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-bromo-2-chloroaniline

There total 10 articles about 3-bromo-2-chloroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-bromo-2-chloro-3-nitrobenzene (3970-37-4) → 3-bromo-2-chlorobenzenamine (56131-46-5)

Guidance literature:

With iron; acetic acid; In ethanol; water; at 20 ℃; for 16h;

Reference yield: 95.0%

N-(3-bromo-2-chlorophenyl)-2-hydroxy-2-methylpropanamide (1287791-79-0) → 3-bromo-2-chlorobenzenamine (56131-46-5)

Guidance literature:

With hydrogenchloride; In ethanol; water; Reflux;

DOI:10.1021/jo200406f

Reference yield:

2-bromo-6-nitroaniline (59255-95-7) → 3-bromo-2-chlorobenzenamine (56131-46-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tert.-butylnitrite; copper dichloride / acetonitrile / 1 h / 60 °C / Inert atmosphere

2: tin(ll) chloride / ethanol / 3 h / Reflux

With tert.-butylnitrite; tin(ll) chloride; copper dichloride; In ethanol; acetonitrile;

upstream raw materials:

1-bromo-2-chloro-3-nitrobenzene

O-3-bromophenyl N,N-diethylcarbamate

O-3-bromo-2-chlorophenyl N,N-diethylcarbamate

2-(3-bromo-2-chlorophenoxy)-2-methylpropanamide

Downstream raw materials:

3-bromo-2-chloro-N-cyclopropylaniline hydrochloride

2-chloro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenylamine

N-(3-bromo-2-chlorophenyl)propane-1-sulfonamide

methyl 2-[(4-{[(3-bromo-2-chlorophenyl)amino]sulfonyl}-2,3-dimethylphenyl)oxy]propanoate