3-bromo-2-chloro-N-cyclopropylaniline hydrochloride

Base Information

• Chemical Name: 3-bromo-2-chloro-N-cyclopropylaniline hydrochloride
• CAS No.: 905438-50-8
• Molecular Formula: C₉H₉BrClN*ClH
• Molecular Weight: 282.995
• Mol file: 905438-50-8.mol

Synonyms:3-bromo-2-chloro-N-cyclopropylaniline hydrochloride

Chemical Property of 3-bromo-2-chloro-N-cyclopropylaniline hydrochloride

Chemical Property:

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Technology Process of 3-bromo-2-chloro-N-cyclopropylaniline hydrochloride

There total 1 articles about 3-bromo-2-chloro-N-cyclopropylaniline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-2-chlorobenzenamine (56131-46-5) + [(1-Ethoxycyclopropyl)oxy]trimethylsilane (27374-25-0) → 3-bromo-2-chloro-N-cyclopropylaniline hydrochloride (905438-50-8)

Guidance literature:

3-bromo-2-chlorobenzenamine; [(1-Ethoxycyclopropyl)oxy]trimethylsilane; In methanol; acetic acid; at 20 - 68 ℃; for 3h;

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 - 60 ℃;

Reference yield:

3-bromo-2-chloro-N-cyclopropylaniline hydrochloride (905438-50-8) → N-(3-bromo-2-chlorophenyl)-5-chloro-N-cyclopropyl-4-nitrothiophene-2-carboxamide (905438-51-9)

Guidance literature:

5-chloro-4-nitrothiophene-2-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

3-bromo-2-chloro-N-cyclopropylaniline hydrochloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 60 ℃;

upstream raw materials:

3-bromo-2-chlorobenzenamine

[(1-Ethoxycyclopropyl)oxy]trimethylsilane

Downstream raw materials:

N-(3-bromo-2-chlorophenyl)-5-chloro-N-cyclopropyl-4-nitrothiophene-2-carboxamide