methyl 2-[(4-{[(3-bromo-2-chlorophenyl)amino]sulfonyl}-2,3-dimethylphenyl)oxy]propanoate

Base Information

• Chemical Name: methyl 2-[(4-{[(3-bromo-2-chlorophenyl)amino]sulfonyl}-2,3-dimethylphenyl)oxy]propanoate
• CAS No.: 1304581-36-9
• Molecular Formula: C₁₈H₁₉BrClNO₅S
• Molecular Weight: 476.776
• Mol file: 1304581-36-9.mol

Synonyms:methyl 2-[(4-{[(3-bromo-2-chlorophenyl)amino]sulfonyl}-2,3-dimethylphenyl)oxy]propanoate

Chemical Property of methyl 2-[(4-{[(3-bromo-2-chlorophenyl)amino]sulfonyl}-2,3-dimethylphenyl)oxy]propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-[(4-{[(3-bromo-2-chlorophenyl)amino]sulfonyl}-2,3-dimethylphenyl)oxy]propanoate

There total 3 articles about methyl 2-[(4-{[(3-bromo-2-chlorophenyl)amino]sulfonyl}-2,3-dimethylphenyl)oxy]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-2-chlorobenzenamine (56131-46-5) + methyl 2-{[4-(chlorosulfonyl)-2,3-dimethylphenyl]oxy}propanoate (1304581-32-5) → methyl 2-[(4-{[(3-bromo-2-chlorophenyl)amino]sulfonyl}-2,3-dimethylphenyl)oxy]propanoate (1304581-36-9)

Guidance literature:

With pyridine; for 16h;

DOI:10.1016/j.bmcl.2011.02.077

Reference yield:

2,3-Dimethylphenol (526-75-0) → methyl 2-[(4-{[(3-bromo-2-chlorophenyl)amino]sulfonyl}-2,3-dimethylphenyl)oxy]propanoate (1304581-36-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 170 °C / Microwave irradiation

2: chlorosulfonic acid / 0 - 20 °C / Inert atmosphere

3: pyridine / 16 h

With pyridine; chlorosulfonic acid; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.02.077

Reference yield:

methyl 2-[(2,3-dimethylphenyl)oxy]propanoate (153472-74-3) → methyl 2-[(4-{[(3-bromo-2-chlorophenyl)amino]sulfonyl}-2,3-dimethylphenyl)oxy]propanoate (1304581-36-9)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorosulfonic acid / 0 - 20 °C / Inert atmosphere

2: pyridine / 16 h

With pyridine; chlorosulfonic acid;

DOI:10.1016/j.bmcl.2011.02.077

upstream raw materials:

3-bromo-2-chlorobenzenamine

methyl 2-{[4-(chlorosulfonyl)-2,3-dimethylphenyl]oxy}propanoate

2,3-Dimethylphenol

methyl 2-[(2,3-dimethylphenyl)oxy]propanoate

Downstream raw materials:

C₂₇H₃₀ClNO₅S

C₂₉H₃₄ClNO₅S

C₂₉H₃₂ClNO₅S

C₂₈H₃₀ClNO₅S