4-Isothiazolecarboxylic acid, methyl ester

Base Information

• Chemical Name: 4-Isothiazolecarboxylic acid, methyl ester
• CAS No.: 56133-37-0
• Molecular Formula: C5H5NO2S
• Molecular Weight: 143.16400
• Mol file: 56133-37-0.mol

Synonyms:methyl isothiazole-4-carboxylate;Isothiazol-4-carbonsaeure-methylester;Isothiazol-4-carbonsaeuremethylester;isothiazole-4-carboxylic acid methyl ester;Isothiazol-4-carboxylsaeuremethylester;

Chemical Property of 4-Isothiazolecarboxylic acid, methyl ester

Chemical Property:

• PSA: 67.43000
• LogP: 0.92970

Purity/Quality:

97% ^*data from raw suppliers

Methylisothiazole-4-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Isothiazolecarboxylic acid, methyl ester

There total 3 articles about 4-Isothiazolecarboxylic acid, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + isothiazole-4-carboxylic acid (822-82-2) → methyl 1,2-thiazole-4-carboxylate (56133-37-0)

Guidance literature:

With thionyl chloride; for 2h; Reflux;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + isothiazole-4-carboxylic acid (822-82-2) → methyl 1,2-thiazole-4-carboxylate (56133-37-0)

Guidance literature:

DOI:10.1039/jr9590003061

Reference yield:

→ methyl 1,2-thiazole-4-carboxylate (56133-37-0)

Guidance literature:

Isothiazol-4-carboxylsaeure;

DOI:10.1021/jo00911a016

upstream raw materials:

diazomethane

isothiazole-4-carboxylic acid

methanol

Downstream raw materials:

Isothiazol-4-carbonsaeure-hydrazid

β-amino-α-methyl propionic acid methyl ester

β-(3,5-dinitro-benzoylamino)-isobutyric acid methyl ester

4-hydroxymethylisothiazole