N-(4-bromophenyl)-2-chloronicotinamide

Base Information

• Chemical Name: N-(4-bromophenyl)-2-chloronicotinamide
• CAS No.: 56149-25-8
• Molecular Formula: C₁₂H₈BrClN₂O
• Molecular Weight: 311.565
• DSSTox Substance ID: DTXSID10404777
• Nikkaji Number: J2.356.781D
• Wikidata: Q82209107
• Mol file: 56149-25-8.mol

Synonyms:N-(4-bromophenyl)-2-chloronicotinamide;N-(4-bromophenyl)-2-chloropyridine-3-carboxamide;56149-25-8;DTXSID10404777;AKOS000150498;EN300-41198;N-(4-bromophenyl)-2-chloro-pyridine-3-carboxamide;Z27786891;F6668-3002

Chemical Property of N-(4-bromophenyl)-2-chloronicotinamide

Chemical Property:

• PSA: 41.99000
• LogP: 3.82280
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 309.95085
• Heavy Atom Count: 17
• Complexity: 269

Purity/Quality:

N-(4-Bromophenyl)-2-chloronicotinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1)Cl)C(=O)NC2=CC=C(C=C2)Br

Technology Process of N-(4-bromophenyl)-2-chloronicotinamide

There total 2 articles about N-(4-bromophenyl)-2-chloronicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Chloronicotinoyl chloride (49609-84-9) + 4-bromo-aniline (106-40-1) → N-(4-bromo-phenyl)-2-chloro-nicotinamide (56149-25-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 8h;

DOI:10.1107/S0108768106015497

Reference yield:

→ N-(4-bromo-phenyl)-2-chloro-nicotinamide (56149-25-8)

Guidance literature:

2-Chlornicotinsaeurechlorid, p-Bromanilin/Et3N;

DOI:10.1007/BF00758649

Reference yield: 73.0%

(2-aminophenyl)diphenylmethanol (52744-72-6) + N-(4-bromo-phenyl)-2-chloro-nicotinamide (56149-25-8) → 11,11-Diphenyl-11H-pyrido[2,1-b]quinazoline-6-carboxylic acid (4-bromo-phenyl)-amide

Guidance literature:

With acetic acid; Heating;

DOI:10.1007/BF02226524

upstream raw materials:

2-Chloronicotinoyl chloride

4-bromo-aniline

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