{4-[(1,3-Thiazol-2-yl)amino]phenyl}acetic acid

Base Information

Chemical Name:{4-[(1,3-Thiazol-2-yl)amino]phenyl}acetic acid
CAS No.:56355-25-0
Molecular Formula:C₁₁H₁₀N₂O₂S
Molecular Weight:234.279
Hs Code.:
DSSTox Substance ID:DTXSID30509793
Wikidata:Q82367658

Synonyms:56355-25-0;{4-[(1,3-Thiazol-2-yl)amino]phenyl}acetic acid;SCHEMBL11589368;DTXSID30509793

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of {4-[(1,3-Thiazol-2-yl)amino]phenyl}acetic acid

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:234.04629874
Heavy Atom Count:16
Complexity:242

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1CC(=O)O)NC2=NC=CS2

Technology Process of {4-[(1,3-Thiazol-2-yl)amino]phenyl}acetic acid

There total 4 articles about {4-[(1,3-Thiazol-2-yl)amino]phenyl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4-Thioureido-phenyl)-acetic acid ethyl ester

: 621-62-5
chloroacetaldehyde diethyl acetal

: 56355-25-0
4-(2-thiazolylamino)phenylacetic acid

Guidance literature:: With toluene-4-sulfonic acid; In acetic acid; at 90 - 95 ℃; for 4h; Yield given;
DOI:10.1248/cpb.31.3424

Reference yield:

: 5438-70-0
ethyl (4-amino-3,5-dibromophenyl)acetate

: 56355-25-0
4-(2-thiazolylamino)phenylacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / NH₄SCN / acetone / 1 h / Ambient temperature

2: 10percent NaOH / 0.17 h / 98 °C

3: p-toluenesulfonic acid / acetic acid / 4 h / 90 - 95 °C

With sodium hydroxide; ammonium thiocyanate; toluene-4-sulfonic acid; In acetic acid; acetone;
DOI:10.1248/cpb.31.3424

Reference yield:

: 88975-57-9
[4-(3-Benzoyl-thioureido)-phenyl]-acetic acid ethyl ester

: 56355-25-0
4-(2-thiazolylamino)phenylacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 10percent NaOH / 0.17 h / 98 °C

2: p-toluenesulfonic acid / acetic acid / 4 h / 90 - 95 °C

With sodium hydroxide; toluene-4-sulfonic acid; In acetic acid;
DOI:10.1248/cpb.31.3424