Ethyl 4-aminophenylacetate

Base Information

• Chemical Name: Ethyl 4-aminophenylacetate
• CAS No.: 5438-70-0
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Hs Code.: 29163400
• Mol file: 5438-70-0.mol

Synonyms:4-Aminophenylacetic acidethyl ester;4-[(Ethoxycarbonyl)methyl]aniline;Ethyl 2-(4-aminophenyl)acetate;Ethyl 4-aminobenzeneacetate;Ethyl 4-aminophenylacetate;Ethylp-aminophenylacetate;NSC 14373;[4-[(Ethoxycarbonyl)methyl]phenyl]amine;p-Aminophenylacetic acid ethyl ester;Aceticacid, (p-aminophenyl)-, ethyl ester (6CI,7CI,8CI);

Chemical Property of Ethyl 4-aminophenylacetate

Chemical Property:

• Appearance/Colour: pinkish-white to beige powder
• Vapor Pressure: 0.000589mmHg at 25°C
• Melting Point: 48-50 °C
• Refractive Index: 1.554
• Boiling Point: 292.5 °C at 760 mmHg
• PKA: 4.55±0.10(Predicted)
• Flash Point: 149.4 °C
• PSA: 52.32000
• Density: 1.112 g/cm³
• LogP: 1.95560
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl 4-aminophenylacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4-aminophenylacetate

There total 19 articles about Ethyl 4-aminophenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ETHYL 4-NITROPHENYLACETATE (5445-26-1) → ethyl (4-amino-3,5-dibromophenyl)acetate (5438-70-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 4h;

Reference yield: 99.5%

ethanol (64-17-5) + 4-aminophenylacetic acid (1197-55-3) → ethyl (4-amino-3,5-dibromophenyl)acetate (5438-70-0)

Guidance literature:

With hydrogenchloride; for 24h; Reflux;

Reference yield: 71.0%

→ ethyl (4-amino-3,5-dibromophenyl)acetate (5438-70-0)

Guidance literature:

upstream raw materials:

ETHYL 4-NITROPHENYLACETATE

ethanol

4-aminophenylacetic acid

ethyl 4-<(trifluoroacetyl)amino>benzeneacetate

Downstream raw materials:

ethyl 2-(4-isothiocyanatophenyl)acetate

(4-benzenesulfonylamino-phenyl)-acetic acid ethyl ester

ethyl 4-<(trifluoroacetyl)amino>benzeneacetate

{4-[5-amino-4-(1H-benzoimidazol-2-yl)-3-oxo-2,3-dihydro-pyrrol-1-yl]-phenyl}-acetic acid ethyl ester

Refernces

• 1、 -. "BIODERIVED EPOXIDE TRIAZINE NETWORKS AND METHODS OF MAKING THE SAME". Paragraph 0048; 0049. . Retrieved 2021/11/26.
• 2、 Jiao, Xiaoyu,Tang, Chunlei,Zhang, Lixun,Zhang, Qing,Zhang, Yongjie,Zhao, Kuantao. "Synthesis and biological evaluation of diaryl urea derivatives as FLT3 inhibitors". supporting information. . Retrieved 2020/10/02.