2-(Pyridin-2-yloxy)ethanol

Base Information

• Chemical Name: 2-(Pyridin-2-yloxy)ethanol
• CAS No.: 56446-64-1
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.15200
• DSSTox Substance ID: DTXSID20480880
• Nikkaji Number: J563.045B

Synonyms:2-(pyridin-2-yloxy)ethanol;56446-64-1;2-(pyridin-2-yloxy)ethan-1-ol;2-pyridin-2-yloxyethanol;2-(2-hydroxyethoxy)pyridine;Ethanol, 2-(2-pyridinyloxy)-;2-(pyridin-2-yloxy)-ethanol;SCHEMBL2416582;DTXSID20480880;RKBOVIXFWKGJLG-UHFFFAOYSA-N;MFCD18384427;AKOS026715764;C90307;EN300-384128;F2147-2323

Chemical Property of 2-(Pyridin-2-yloxy)ethanol

Chemical Property:

• PSA: 42.35000
• LogP: 0.45270
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 139.063328530
• Heavy Atom Count: 10
• Complexity: 87.7

Purity/Quality:

99% ^*data from raw suppliers

2-(Pyridin-2-yloxy)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)OCCO

Technology Process of 2-(Pyridin-2-yloxy)ethanol

There total 6 articles about 2-(Pyridin-2-yloxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-bromo-pyridine (109-04-6) + ethylene glycol (107-21-1) → 2-(pyridine-2-yloxy)ethan-1-ol (56446-64-1)

Guidance literature:

With potassium carbonate; copper dichloride; at 20 - 130 ℃; for 16h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tetlet.2016.11.061

Reference yield: 6.6%

2-chloropyridine (109-09-1) + ethylene glycol (107-21-1) → 2-(pyridine-2-yloxy)ethan-1-ol (56446-64-1) + 2,2'-ethane-1,2-diyldioxy-bis-pyridine (56446-65-2)

Guidance literature:

With potassium hydroxide; 18-crown-6 ether; In toluene; for 12h; Heating;

DOI:10.1055/s-1982-29838

Reference yield:

2-iodopyridine (5029-67-4) + tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate (301673-16-5) + ethylene glycol (107-21-1) → 2-(pyridine-2-yloxy)ethan-1-ol (56446-64-1) + tert-butyl 3-(hydroxymethyl)-4-(pyridin-2-yl)piperazine-1-carboxylate

Guidance literature:

With potassium phosphate; copper(l) iodide; In isopropyl alcohol; at 90 ℃; Overall yield = 143 mg;

upstream raw materials:

2-chloropyridine

ethylene glycol

2-bromo-pyridine

2-iodopyridine

Downstream raw materials:

1-(2-hydroxyethyl)pyridin-2-one

2,2'-ethane-1,2-diyldioxy-bis-pyridine

2-[2-(4-nitrophenoxy)ethoxy]pyridine

4-chloro-3-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-N-methyl-N-{2-[2-(pyridin-2-yloxy)-ethoxy]-phenyl}-benzamide

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