5-phenyl-1H-pyrrole-3-carbaldehyde

Base Information

• Chemical Name: 5-phenyl-1H-pyrrole-3-carbaldehyde
• CAS No.: 56448-22-7
• Molecular Formula: C11H9NO
• Molecular Weight: 171.199
• Mol file: 56448-22-7.mol

Synonyms:5-PHENYL-1H-PYRROLE-3-CARBALDEHYDE;.2-Phenyl-4-formyl-pyrrol;2-phenyl-4-formylpyrrole;Pyrrole Related Compound 4 (2-Phenyl-4-formylpyrrole);

Chemical Property of 5-phenyl-1H-pyrrole-3-carbaldehyde

Chemical Property:

• PSA: 32.86000
• LogP: 2.49420

Purity/Quality:

99.0% Min ^*data from raw suppliers

5-Phenyl-1H-pyrrole-3-carbaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-?Phenyl-?1H-?pyrrole-?3-?carbaldehyde is an impurity in the synthesis of Vonoprazan which acts as a competitive potassium acid blocker.

Technology Process of 5-phenyl-1H-pyrrole-3-carbaldehyde

There total 13 articles about 5-phenyl-1H-pyrrole-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

furan (110-00-9) + benzenecarbothioamide (2227-79-4) → 5-phenyl-1H pyrrole-3-carboxaldehyde (56448-22-7)

Guidance literature:

In methanol; for 2h; Ambient temperature; Irradiation;

DOI:10.1039/c39930000437

Reference yield: 62.0%

(5-phenyl-1H-pyrrol-3-yl)methanol (881673-95-6) → 5-phenyl-1H pyrrole-3-carboxaldehyde (56448-22-7)

Guidance literature:

With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In acetonitrile; at 20 ℃; for 1.5h; Molecular sieve;

Reference yield: 61.0%

5-bromo-1H-pyrrole-3-carboxaldehyde (881676-32-0) + phenylboronic acid (98-80-6) → 5-phenyl-1H pyrrole-3-carboxaldehyde (56448-22-7)

Guidance literature:

5-bromo-1H-pyrrole-3-carboxaldehyde; phenylboronic acid; With potassium carbonate; In 1,4-dioxane; Inert atmosphere;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 105 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol503078h

upstream raw materials:

furan

benzenecarbothioamide

5-bromo-1H-pyrrole-3-carboxaldehyde

(5-phenyl-1H-pyrrol-3-yl)methanol

Downstream raw materials:

C₁₅H₁₇NO₂

1-[(3-nitrophenyl)sulfonyl]-5-phenyl-1H-pyrrole-3-carbaldehyde

1-{[4-(methylsulfonyl)phenyl]sulfonyl}-5-phenyl-1H-pyrrole-3-carbaldehyde

5-phenyl-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde

Refernces

• 1、 Oda,Machida. "Photoreaction of thiobenzamide with furans in methanol. Facile construction of the arylpyrrole ring system". . p. 437 - 438. Retrieved 1993.
• 2、 -. "Proton pump inhibitors". Paragraph 0239. . Retrieved 2015/11/16.