2-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-5-methoxybenzamide

Base Information

Chemical Name:2-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-5-methoxybenzamide
CAS No.:56658-05-0
Molecular Formula:C12H16BrNO3
Molecular Weight:302.16400
Hs Code.:
DSSTox Substance ID:DTXSID00369705
Wikidata:Q82156970
ChEMBL ID:CHEMBL3185681

Synonyms:56658-05-0;2-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-5-methoxybenzamide;Benzamide, 2-bromo-N-(2-hydroxy-1,1-dimethylethyl)-5-methoxy-;N1-(2-hydroxy-1,1-dimethylethyl)-2-bromo-5-methoxybenzamide;Maybridge3_005948;Oprea1_312640;MLS000861764;CHEMBL3185681;SCHEMBL11833701;DTXSID00369705;HMS1447O08;HMS2776B23;CCG-47053;AKOS005837071;IDI1_017335;SMR000460548;A1-05013;SR-01000636701-1

Suppliers and Price of 2-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-5-methoxybenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
2-Bromo-N-(1-hydroxy-2-methylpropan-2-yl)-5-methoxybenzamide 95%
2.500g
$ 1238.00

American Custom Chemicals Corporation
2-BROMO-N-(1-HYDROXY-2-METHYLPROPAN-2-YL)-5-METHOXYBENZAMIDE 95.00%
5MG
$ 505.37

A1 Biochem Labs
2-Bromo-N-(1-hydroxy-2-methylpropan-2-yl)-5-methoxybenzamide 95%
2.5 g
$ 750.00

Total 0 raw suppliers

Chemical Property of 2-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-5-methoxybenzamide

Chemical Property:

PSA：62.05000
LogP:2.53320
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:301.03136
Heavy Atom Count:17
Complexity:271

Purity/Quality:: 2-Bromo-N-(1-hydroxy-2-methylpropan-2-yl)-5-methoxybenzamide 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(CO)NC(=O)C1=C(C=CC(=C1)OC)Br

Technology Process of 2-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-5-methoxybenzamide

There total 4 articles about 2-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-5-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56658-04-9
2-bromo-5-methoxybenzoyl chloride

: 124-68-5
2-Amino-2-methyl-1-propanol

: 56658-05-0
2-bromo-N-(2-hydroxy-1,1-dimethyl-ethyl)-5-methoxy-benzamide

Guidance literature:: In dichloromethane;
DOI:10.1016/j.jorganchem.2005.05.026

Reference yield:

: 22921-68-2
2-bromo-5-methoxy-benzoic acid

: 56658-05-0
2-bromo-N-(2-hydroxy-1,1-dimethyl-ethyl)-5-methoxy-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride

2: CH₂Cl₂

With thionyl chloride; In dichloromethane;
DOI:10.1016/j.jorganchem.2005.05.026

Reference yield:

: 22921-68-2
2-bromo-5-methoxy-benzoic acid

: 56658-05-0
2-bromo-N-(2-hydroxy-1,1-dimethyl-ethyl)-5-methoxy-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0 - 20 °C / Inert atmosphere

2: triethylamine / 1,4-dioxane / 1 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jacs.7b13492