Ethanone, 2-bromo-2-(4-methoxyphenyl)-1-phenyl-

Base Information

• Chemical Name: Ethanone, 2-bromo-2-(4-methoxyphenyl)-1-phenyl-
• CAS No.: 56913-16-7
• Molecular Formula: C15H13BrO2
• Molecular Weight: 305.171
• DSSTox Substance ID: DTXSID20399281
• Nikkaji Number: J3.197.191H
• Mol file: 56913-16-7.mol

Synonyms:Ethanone, 2-bromo-2-(4-methoxyphenyl)-1-phenyl-;56913-16-7;p-methoxybenzoylbenzyl bromide;SCHEMBL7017619;DTXSID20399281;CMUKLFHIVXQAQK-UHFFFAOYSA-N;2-(4-Methoxyphenyl)-2-bromo-1-phenylethanone

Chemical Property of Ethanone, 2-bromo-2-(4-methoxyphenyl)-1-phenyl-

Chemical Property:

• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 304.00989
• Heavy Atom Count: 18
• Complexity: 266

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(C(=O)C2=CC=CC=C2)Br

Technology Process of Ethanone, 2-bromo-2-(4-methoxyphenyl)-1-phenyl-

There total 11 articles about Ethanone, 2-bromo-2-(4-methoxyphenyl)-1-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

trans-(2R,3R)-2-phenyl-3-(4-(trifluoromethoxy)phenyl)oxirane (5814-81-3,14802-05-2,67042-23-3,70288-32-3,70332-47-7) → 2-bromo-1-phenyl-2-(4'-methoxyphenyl)-1-ethanone (56913-16-7)

Guidance literature:

With cis-dichlorobis(2,2′-bipyridine)ruthenium(II); carbon tetrabromide; In acetonitrile; for 5h; Solvent; Reagent/catalyst; regioselective reaction; Irradiation;

DOI:10.1039/c3ob41245h

Reference yield: 65.0%

2-(4-methoxyphenyl)acetophenone (24845-40-7) → 2-bromo-1-phenyl-2-(4'-methoxyphenyl)-1-ethanone (56913-16-7)

Guidance literature:

With bromine; In tetrachloromethane; Irradiation;

DOI:10.1021/jm00367a014

Reference yield:

4-methoxyphenyl-acetic chloride (4693-91-8) → 2-bromo-1-phenyl-2-(4'-methoxyphenyl)-1-ethanone (56913-16-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 5.22 g / AlCl₃ / CH₂Cl₂ / Ambient temperature

2: 65 percent / Br₂ / CCl₄ / Irradiation

With aluminium trichloride; bromine; In tetrachloromethane; dichloromethane;

DOI:10.1021/jm00367a014

upstream raw materials:

2-(4-methoxyphenyl)acetophenone

4-methoxyphenyl-acetic chloride

benzene

2-(4-methoxyphenyl)acetamide

Downstream raw materials:

4'-methoxybenzoin

α-amino-4'-methoxy-deoxybenzoin

C₁₉H₁₅N₃O

C₂₃H₁₆FN₃OS