2-Hydroxy-5-phenoxybenzoic acid

Base Information

• Chemical Name: 2-Hydroxy-5-phenoxybenzoic acid
• CAS No.: 56926-42-2
• Molecular Formula: C13H10O4
• Molecular Weight: 230.22
• European Community (EC) Number: 836-713-6
• Mol file: 56926-42-2.mol

Synonyms:2-hydroxy-5-phenoxybenzoic acid;56926-42-2;2-hydroxy-5-phenoxybenzoicacid;SCHEMBL2533361;AKOS009278238;CS-0262405;EN300-82458;Z367679252

Chemical Property of 2-Hydroxy-5-phenoxybenzoic acid

Chemical Property:

• XLogP3: 4.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 230.05790880
• Heavy Atom Count: 17
• Complexity: 260

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OC2=CC(=C(C=C2)O)C(=O)O

Technology Process of 2-Hydroxy-5-phenoxybenzoic acid

There total 7 articles about 2-Hydroxy-5-phenoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

n-butyllithium (109-72-8,29786-93-4) + 2-bromo-4-phenoxy-phenol (54582-60-4) → 2-hydroxy-5-phenoxy-benzoic acid (56926-42-2)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; dichloromethane;

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + 4-Phenoxyphenol (831-82-3) → 2-hydroxy-5-phenoxy-benzoic acid (56926-42-2)

Guidance literature:

With potassium carbonate; at 130 ℃;

DOI:10.1021/jm00243a015

Reference yield:

2-methoxy-5-phenoxy-benzoic acid (63987-24-6) → 2-hydroxy-5-phenoxy-benzoic acid (56926-42-2)

Guidance literature:

With hydrogen iodide; acetic anhydride; acetic acid;

DOI:10.1021/jo50002a021

upstream raw materials:

2-methoxy-5-phenoxy-benzoic acid

carbon dioxide

4-Phenoxyphenol

2-methyl-4-bromoanisole

Downstream raw materials:

2-hydroxy-5-phenoxybenzoic acid methyl ester

Ethyl-2,4-dioxo-4-(2'-hydroxy-5'-phenoxyphenyl)-butyrat

Ethyl-2-benzyloxy-5-phenoxybenzoat

2-Benzyloxy-5-phenoxybenzoesaeure