Propanoic acid, 2-(1-naphthalenyloxy)-, (2S)-

Base Information

• Chemical Name: Propanoic acid, 2-(1-naphthalenyloxy)-, (2S)-
• CAS No.: 57128-28-6
• Molecular Formula: C₁₃H₁₂O₃
• Molecular Weight: 216.236
• Mol file: 57128-28-6.mol

Synonyms:(S)-2-[1]Naphthyloxy-propionsaeure;(R)-2-(1-Naphthoxy)propionsaeure;(S)-2-[1]naphthyloxy-propionic acid;(S)-2-(Naphthalen-1-yloxy)-propionic acid;

Chemical Property of Propanoic acid, 2-(1-naphthalenyloxy)-, (2S)-

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• PSA: 46.53000
• LogP: 2.69170

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanoic acid, 2-(1-naphthalenyloxy)-, (2S)-

There total 11 articles about Propanoic acid, 2-(1-naphthalenyloxy)-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(S)-(+)-ethyl 2-(naphthalen-1-yloxy)propionate (57057-81-5) → (S)-2-(1-naphthoxy)propanoic acid (57128-28-6)

Guidance literature:

With sodium hydroxide; In methanol; for 2h; Ambient temperature;

Reference yield: 29.0%

2-Methyl-2-α-naphthylacetic acid (13949-67-2) → (R)-2-Methyl-2-α-naphthylacetic acid (57128-29-7) + (S)-2-(1-naphthoxy)propanoic acid (57128-28-6)

Guidance literature:

With Chiralcel OD-H; In hexane; isopropyl alcohol; trifluoroacetic acid; Reagent/catalyst; Solvent; Resolution of racemate;

DOI:10.1007/s11172-021-3165-8

Reference yield:

C22H19F2NO3 → (R)-2-Methyl-2-α-naphthylacetic acid (57128-29-7) + (S)-2-(1-naphthoxy)propanoic acid (57128-28-6)

Guidance literature:

With water; sodium carbonate; In acetonitrile; for 1h; Overall yield = 72 percent; Overall yield = 46.7 mg;

DOI:10.1007/s11172-019-2550-z

upstream raw materials:

(S)-(+)-ethyl 2-(naphthalen-1-yloxy)propionate

2-Methyl-2-α-naphthylacetic acid

bis(1-naphthyl)methanol

α-naphthol

Downstream raw materials:

2-[(S)-2-(Naphthalen-1-yloxy)-propionylamino]-3-phenyl-propionic acid