Di-1-naphthylmethanol

Base Information

• Chemical Name: Di-1-naphthylmethanol
• CAS No.: 62784-66-1
• Molecular Formula: C21H16O
• Molecular Weight: 284.357
• Hs Code.: 2906299090
• Mol file: 62784-66-1.mol

Synonyms:Di-1-naphthylmethanol

Chemical Property of Di-1-naphthylmethanol

Chemical Property:

• Vapor Pressure: 5.55E-11mmHg at 25°C
• Melting Point: 148 °C
• Refractive Index: 1.718
• Boiling Point: 504.1°C at 760 mmHg
• PKA: 13.28±0.20(Predicted)
• Flash Point: 211.1°C
• PSA: 20.23000
• Density: 1.208g/cm³
• LogP: 5.07470
• Solubility.: soluble in Toluene

Purity/Quality:

98%,99%, ^*data from raw suppliers

Di-1-naphthylmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Di-1-naphthylmethanol

There total 2 articles about Di-1-naphthylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

bis(α-naphthyl)methyl 3-phenyl-2-(1H-pyrrol-1-yl)propanoate → bis(1-naphthyl)methanol (62784-66-1) + (R)-3-phenyl-2-(1H-pyrrol-1-yl)propan-1-ol + (S)-3-phenyl-2-(1H-pyrrol-1-yl)propan-1-ol (123366-90-5)

Guidance literature:

bis(α-naphthyl)methyl 3-phenyl-2-(1H-pyrrol-1-yl)propanoate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

In hexane; isopropyl alcohol; Resolution of racemate;

Reference yield: 95.0%

(S)-di-(1-naphthyl)methyl α-(phenylthio)propanoate (1213744-28-5) → bis(1-naphthyl)methanol (62784-66-1) + (S)-2-(phenylthio)-1-propanol (108033-49-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h;

DOI:10.1002/anie.201007860

Reference yield: 49.0%

naproxen (23981-80-8) + bis(1-naphthyl)methanol (62784-66-1) → (S)-naproxen di(1-naphthyl)methyl ester (1116086-50-0) + (2S)-2-(6-methoxy(2-naphthyl))propanoic acid (22204-53-1) + (R)-2-(6-methoxy-2-naphthyl)propionic acid (23979-41-1)

Guidance literature:

With (-)-(S)-β-Np-BTM; p-Methoxybenzoic anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h; optical yield given as %ee; Resolution of racemate;

DOI:10.1002/ejoc.200800942

upstream raw materials:

(S)-di-(1-naphthyl)methyl α-(phenylthio)propanoate

Downstream raw materials:

1-(bromo(1-naphthyl)methyl)naphthalene

4-(di-[1]naphthyl-methyl)-aniline

1,1'-dinaphthylmethane

bis(naphthalen-1-yl)methanone

Refernces

• 1、 Yang, Xing,Birman, Vladimir B.. "Nonenzymatic dynamic kinetic resolution of α-(arylthio)- and α-(alkylthio)alkanoic acids". supporting information; experimental part. p. 5553 - 5555. Retrieved 2011/07/09.