2-BROMO-1-(4-BromoPHENYL)-1-ETHANONE OXIME

Base Information

• Chemical Name: 2-BROMO-1-(4-BromoPHENYL)-1-ETHANONE OXIME
• CAS No.: 57342-22-0
• Molecular Formula: C8H7Br2NO
• Molecular Weight: 292.958
• Mol file: 57342-22-0.mol

Synonyms:p-Brom-phenacylbromid-oxime;2,4'-dibromoacetophenone oxime;2-BROMO-1-(4-BROMOPHENYL)-1-ETHANONE OXIME;

Chemical Property of 2-BROMO-1-(4-BromoPHENYL)-1-ETHANONE OXIME

Chemical Property:

• PSA: 32.59000
• LogP: 3.02230

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-1-(4-BromoPHENYL)-1-ETHANONE OXIME

There total 2 articles about 2-BROMO-1-(4-BromoPHENYL)-1-ETHANONE OXIME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

para-bromophenacyl bromide (99-73-0,132309-76-3) → 2-bromo-1-(4-bromophenyl)ethanone oxime (57342-22-0)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In ethanol; for 4h; Reflux;

DOI:10.1021/jm1016279

Reference yield:

para-bromoacetophenone (99-90-1) → 2-bromo-1-(4-bromophenyl)ethanone oxime (57342-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(ll) bromide / chloroform; ethyl acetate

2: sodium acetate; hydroxylamine hydrochloride / water

With hydroxylamine hydrochloride; sodium acetate; copper(ll) bromide; In chloroform; water; ethyl acetate;

DOI:10.1021/acs.orglett.2c00024

Reference yield: 98.0%

2-bromo-1-(4-bromophenyl)ethanone oxime (57342-22-0) + phenacyldimethylsulfonium bromide (5667-47-0) → (3-(4-bromophenyl)-4,5-dihydroisoxazol-5-yl)(phenyl)methanone (17492-59-0)

Guidance literature:

With sodium carbonate; In dichloromethane; at 20 ℃; for 4h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tetlet.2018.12.062

upstream raw materials:

para-bromophenacyl bromide

para-bromoacetophenone

Downstream raw materials:

2-ethyl-3-(4-bromo-β-hydroxyimino-phenethyl)-4-methyl-thiazolium; bromide

[2-(4-bromo-phenyl)-2-hydroxyimino-ethyl]-tributyl-phosphonium; bromide

3-(4-bromo-phenyl)-4,4a,5,7a-tetrahydro-cyclopenta[e][1,2]oxazine

[2-(4-bromo-phenyl)-2-hydroxyimino-ethyl]-triphenyl-phosphonium; bromide