(3-(4-bromophenyl)-4,5-dihydroisoxazol-5-yl)(phenyl)methanone

Base Information

• Chemical Name: (3-(4-bromophenyl)-4,5-dihydroisoxazol-5-yl)(phenyl)methanone
• CAS No.: 17492-59-0
• Molecular Formula: C₁₆H₁₂BrNO₂
• Molecular Weight: 330.181
• Mol file: 17492-59-0.mol

Synonyms:(3-(4-bromophenyl)-4,5-dihydroisoxazol-5-yl)(phenyl)methanone

Chemical Property of (3-(4-bromophenyl)-4,5-dihydroisoxazol-5-yl)(phenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-(4-bromophenyl)-4,5-dihydroisoxazol-5-yl)(phenyl)methanone

There total 4 articles about (3-(4-bromophenyl)-4,5-dihydroisoxazol-5-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-bromo-1-(4-bromophenyl)ethanone oxime (57342-22-0) + phenacyldimethylsulfonium bromide (5667-47-0) → (3-(4-bromophenyl)-4,5-dihydroisoxazol-5-yl)(phenyl)methanone (17492-59-0)

Guidance literature:

With sodium carbonate; In dichloromethane; at 20 ℃; for 4h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tetlet.2018.12.062

Reference yield: 56.0%

4-bromo-benzaldehyde (1122-91-4) + Phenyl vinyl ketone (768-03-6,26742-84-7) → (3-(4-bromophenyl)-4,5-dihydroisoxazol-5-yl)(phenyl)methanone (17492-59-0)

Guidance literature:

4-bromo-benzaldehyde; With toluene-4-sulfonic acid hydrazide;

Phenyl vinyl ketone; With tert.-butylnitrite; N,N,N,N,-tetramethylethylenediamine; copper dichloride; In tetrahydrofuran; at 65 ℃; for 24h;

DOI:10.1039/d1sc02352g

Reference yield:

3-morpholin-4-yl-1-phenyl-propan-1-one (2298-48-8) + 4-bromo-N-hydroxybenzenecarboximidoyl chloride (29203-58-5) → (3-(4-bromophenyl)-4,5-dihydroisoxazol-5-yl)(phenyl)methanone (17492-59-0)

Guidance literature:

With 3-morpholino-1-phenylpropan-1-one hydrochloride; In ethanol; Heating;

upstream raw materials:

3-morpholin-4-yl-1-phenyl-propan-1-one

4-bromo-N-hydroxybenzenecarboximidoyl chloride

2-bromo-1-(4-bromophenyl)ethanone oxime

phenacyldimethylsulfonium bromide