4-[(4-Chlorophenyl)methylidene]-2-phenyl-1,3-oxazol-5-one

Base Information

Chemical Name:4-[(4-Chlorophenyl)methylidene]-2-phenyl-1,3-oxazol-5-one
CAS No.:57427-77-7
Molecular Formula:C₁₆H₁₀ClNO₂
Molecular Weight:283.714
Hs Code.:
DSSTox Substance ID:DTXSID90291187
Wikidata:Q70000094
ChEMBL ID:CHEMBL4525387

Synonyms:4-[(4-chlorophenyl)methylidene]-2-phenyl-1,3-oxazol-5-one;4-[(4-chlorophenyl)methylidene]-2-phenyl-4,5-dihydro-1,3-oxazol-5-one;Maybridge1_001084;NCIOpen2_003973;CBDivE_012415;CHEMBL4525387;SCHEMBL10597715;DTXSID90291187;5(4H)-Oxazolone, 4-[(4-chlorophenyl)methylene]-2-phenyl-, (4Z)-;AKOS030229996;NCI60_041617;4-(4'-chlorobenzylidene)-2-phenyl-5(4h)-oxazolone

Suppliers and Price of 4-[(4-Chlorophenyl)methylidene]-2-phenyl-1,3-oxazol-5-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of 4-[(4-Chlorophenyl)methylidene]-2-phenyl-1,3-oxazol-5-one

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:283.0400063
Heavy Atom Count:20
Complexity:430

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=NC(=CC3=CC=C(C=C3)Cl)C(=O)O2

Technology Process of 4-[(4-Chlorophenyl)methylidene]-2-phenyl-1,3-oxazol-5-one

There total 6 articles about 4-[(4-Chlorophenyl)methylidene]-2-phenyl-1,3-oxazol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2
Hippuric Acid

: 104-88-1
4-chlorobenzaldehyde

: 15601-44-2,57427-77-7,57427-86-8
(Z)-2-phenyl-4-(4-chlorobenzylidene)-5(4H)-oxazolone

Guidance literature:: With 1-butyl-3-methylimidazolium phosphotungstate; acetic anhydride; at 80 ℃; for 1h;
DOI:10.1016/j.apcata.2011.02.004

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 98-88-4
benzoyl chloride

: 56-40-6,18875-39-3,25718-94-9
glycine

: 15601-44-2,57427-77-7,57427-86-8
(Z)-2-phenyl-4-(4-chlorobenzylidene)-5(4H)-oxazolone

Guidance literature:: benzoyl chloride; glycine; With sodium acetate; acetic anhydride; at 60 ℃; for 0.05h; Sonication;

4-chlorobenzaldehyde; at 60 ℃; for 0.05h; Sonication;
DOI:10.24820/ark.5550190.p010.544

Reference yield:

: 495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2
Hippuric Acid

: 15601-44-2,57427-77-7,57427-86-8
(Z)-2-phenyl-4-(4-chlorobenzylidene)-5(4H)-oxazolone

Guidance literature:: Multi-step reaction with 2 steps

1: Ac₂O; AcONa

With sodium acetate; acetic anhydride;
DOI:10.1016/S0040-4039(03)01353-4