2-(2-Chlorophenyl)-1-phenyl-1H-benzo[d]imidazole

Base Information

• Chemical Name: 2-(2-Chlorophenyl)-1-phenyl-1H-benzo[d]imidazole
• CAS No.: 57492-47-4
• Molecular Formula: C19H13ClN2
• Molecular Weight: 304.779
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID90481223
• Wikidata: Q82316501
• Mol file: 57492-47-4.mol

Synonyms:2-(2-Chlorophenyl)-1-phenyl-1H-benzo[d]imidazole;57492-47-4;2-(2-chlorophenyl)-1-phenylbenzimidazole;SCHEMBL8021269;DTXSID90481223;AMY28790

Chemical Property of 2-(2-Chlorophenyl)-1-phenyl-1H-benzo[d]imidazole

Chemical Property:

• PSA: 17.82000
• LogP: 5.34590
• Storage Temp.: 2-8°C
• XLogP3: 5.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 304.0767261
• Heavy Atom Count: 22
• Complexity: 368

Purity/Quality:

98%Min ^*data from raw suppliers

2-(2-Chlorophenyl)-1-phenyl-1H-benzo[d]imidazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)N2C3=CC=CC=C3N=C2C4=CC=CC=C4Cl

Technology Process of 2-(2-Chlorophenyl)-1-phenyl-1H-benzo[d]imidazole

There total 8 articles about 2-(2-Chlorophenyl)-1-phenyl-1H-benzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-chloro-benzaldehyde (89-98-5) + N-phenyl-1,2-benzenediamine (534-85-0) → 2-(2-chlorophenyl)-1-phenylbenzimidazole (57492-47-4)

Guidance literature:

With sodium metabisulfite; In N,N-dimethyl-formamide; at 100 ℃; for 0.1h; Microwave irradiation;

DOI:10.1002/jhet.1058

Reference yield:

o-chlorobenzoyl chloride (609-65-4) + N-phenyl-1,2-benzenediamine (534-85-0) → 2-(2-chlorophenyl)-1-phenylbenzimidazole (57492-47-4)

Guidance literature:

With sodium hydroxide; trichlorophosphate; In diethyl ether; chloroform; ethyl acetate;

Reference yield:

2-nitro-N-phenylaniline (119-75-5) → 2-(2-chlorophenyl)-1-phenylbenzimidazole (57492-47-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.6 g / hydrazine hydrate / 5percent Pd/C / ethanol / 2 h / Heating

2: 2.7 g / pyridine / 3 h / Ambient temperature

3: 0.8 g / 2-chlorobenzoyl chloride / 3 h / 200 °C

With o-chlorobenzoyl chloride; hydrazine hydrate; palladium on activated charcoal; In pyridine; ethanol;

upstream raw materials:

N-(2-chlorophenyl)-N-(2-nitrophenyl)amine

2-nitro-N-phenylaniline

o-chloroaniline

1,2-Dinitrobenzene

Downstream raw materials:

benzimidazo<1,2-f>phenanthridine

1,2-diphenyl-1H-benzoimidazole

Refernces

• 1、 -. "Methods of treating or preventing interstitial cystitis". . . Retrieved 2008/06/13.
• 2、 -. "METHODS FOR TREATING A PHYSIOLOGICAL DISORDER ASSOCIATED WITH BETA-AMYLOID PEPTIDE". . . Retrieved 2008/06/13.