2-CHLORO-6-METHYL-QUINOLINE

Base Information

• Chemical Name: 2-CHLORO-6-METHYL-QUINOLINE
• CAS No.: 4295-11-8
• Molecular Formula: C10H8ClN
• Molecular Weight: 177.633
• Hs Code.: 2933499090
• Mol file: 4295-11-8.mol

Synonyms:2-Chloro-6-methylquinoline;

Chemical Property of 2-CHLORO-6-METHYL-QUINOLINE

Chemical Property:

• Vapor Pressure: 0.00463mmHg at 25°C
• Melting Point: 111-114 °C
• Refractive Index: 1.634
• Boiling Point: 286.1 °C at 760 mmHg
• PKA: 0.55±0.43(Predicted)
• Flash Point: 154.2 °C
• PSA: 12.89000
• Density: 1.225 g/cm³
• LogP: 3.19660
• Storage Temp.: Room temperature.

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-6-methylquinoline 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-6-METHYL-QUINOLINE

There total 19 articles about 2-CHLORO-6-METHYL-QUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-methylquinolin-2(1H)-one (4053-34-3) → 2-chloro-6-methylquinoline (4295-11-8)

Guidance literature:

With trichlorophosphate; at 60 ℃; Inert atmosphere;

Reference yield: 87.0%

1,6-dimethyl-2(1H)-quinolinone (29969-49-1) → 2-chloro-6-methylquinoline (4295-11-8)

Guidance literature:

With trichloroisocyanuric acid; triphenylphosphine; In neat (no solvent); at 160 - 170 ℃; for 14h; Inert atmosphere;

DOI:10.3987/COM-15-13234

Reference yield: 70.0%

6-methylquinoline-N-oxide (4053-42-3) → 2-chloro-6-methylquinoline (4295-11-8)

Guidance literature:

With trichloroacetonitrile; triphenylphosphine; In toluene; at 115 ℃; for 4h; regioselective reaction; Sealed tube;

DOI:10.1002/ejoc.201501567

upstream raw materials:

6-methylquinolin-2(1H)-one

1,6-dimethyl-2(1H)-quinolinone

phosphorus pentachloride

trichlorophosphate

Downstream raw materials:

2-amino-6-methylquinoline

2-chloroquinoline-6-carbaldehyde

7-(2,3,4,5-tetrahydro-5-methyl-2-phenyl-3-oxopyridazin-6-yl)triazolo<4,3-a>quinoline

7-(2,3,4,5-tetrahydro-5-methyl-2-phenyl-3-oxopyridazin-6-yl)tetrazolo<1,5-a>quinoline

Refernces

• 1、 Qiao, Kai,Wan, Li,Sun, Xiaoning,Zhang, Kai,Zhu, Ning,Li, Xin,Guo, Kai. "Regioselective Chlorination of Quinoline N-Oxides and Isoquinoline N-Oxides Using PPh3/Cl3CCN". . p. 1606 - 1611. Retrieved 2016/04/05.
• 2、 -. "2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition". Page/Page column 13; 14; 42. . Retrieved 2016/01/09.