3-Thiophenecarboxylic acid, 5-(4-aminophenyl)-2-[[(2,6-difluorophenyl)methyl](ethoxycarbonyl)amino ]-4-[[(2-methoxyethyl)methylamino]methyl]-, ethyl ester

Base Information

Chemical Name:3-Thiophenecarboxylic acid, 5-(4-aminophenyl)-2-[[(2,6-difluorophenyl)methyl](ethoxycarbonyl)amino ]-4-[[(2-methoxyethyl)methylamino]methyl]-, ethyl ester
CAS No.:577780-07-5
Molecular Formula:C28H33F2N3O5S
Molecular Weight:561.65
Hs Code.:

3-Thiophenecarboxylic acid,
5-(4-aminophenyl)-2-[[(2,6-difluorophenyl)methyl](ethoxycarbonyl)amino
]-4-[[(2-methoxyethyl)methylamino]methyl]-, ethyl ester

Synonyms:

Suppliers and Price of 3-Thiophenecarboxylic acid, 5-(4-aminophenyl)-2-[[(2,6-difluorophenyl)methyl](ethoxycarbonyl)amino ]-4-[[(2-methoxyethyl)methylamino]methyl]-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 4 raw suppliers

Chemical Property of 3-Thiophenecarboxylic acid, 5-(4-aminophenyl)-2-[[(2,6-difluorophenyl)methyl](ethoxycarbonyl)amino ]-4-[[(2-methoxyethyl)methylamino]methyl]-, ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Thiophenecarboxylic acid, 5-(4-aminophenyl)-2-[[(2,6-difluorophenyl)methyl](ethoxycarbonyl)amino ]-4-[[(2-methoxyethyl)methylamino]methyl]-, ethyl ester

There total 5 articles about 3-Thiophenecarboxylic acid, 5-(4-aminophenyl)-2-[[(2,6-difluorophenyl)methyl](ethoxycarbonyl)amino ]-4-[[(2-methoxyethyl)methylamino]methyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 308832-01-1
ethyl 2-[(2,6-difluorobenzyl)(ethoxycarbonyl)amino]-4-{[(2-methoxyethyl)(methyl)amino]methyl}-5-(4-nitrophenyl)thiophene-3-carboxylate

: 577780-07-5
ethyl 5-(4-aminophenyl)-2-[(2,6-difluorobenzyl)(ethoxycarbonyl)amino]-4-{[(2-methoxyethyl)(methyl)amino]methyl}thiophene-3-carboxylate

Guidance literature:: With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In diethyl ether; ethanol; water; for 1h;

Reference yield:

: 308831-93-8
2-((ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester

: 577780-07-5
ethyl 5-(4-aminophenyl)-2-[(2,6-difluorobenzyl)(ethoxycarbonyl)amino]-4-{[(2-methoxyethyl)(methyl)amino]methyl}thiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 44 h / 20 °C

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / ethyl acetate / 3.5 h / Reflux

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

4: hydrogenchloride; palladium 10% on activated carbon; hydrogen / diethyl ether; ethanol / 1 h / 20 °C / 760.05 Torr

With hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); palladium 10% on activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; In diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm200216q

Reference yield:

: 308831-94-9
2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester

: 577780-07-5
ethyl 5-(4-aminophenyl)-2-[(2,6-difluorobenzyl)(ethoxycarbonyl)amino]-4-{[(2-methoxyethyl)(methyl)amino]methyl}thiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / ethyl acetate / 3.5 h / Reflux

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

3: hydrogenchloride; palladium 10% on activated carbon; hydrogen / diethyl ether; ethanol / 1 h / 20 °C / 760.05 Torr

With hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In diethyl ether; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm200216q