3-Thiophenecarboxylic acid, 2-[[(2,6-difluorophenyl)methyl](ethoxycarbonyl)amino]-5-[4-[[(ethylamino) carbonyl]amino]phenyl]-4-[[(2-methoxyethyl)methylamino]methyl]-, ethyl ester

Base Information

Chemical Name:3-Thiophenecarboxylic acid, 2-[[(2,6-difluorophenyl)methyl](ethoxycarbonyl)amino]-5-[4-[[(ethylamino) carbonyl]amino]phenyl]-4-[[(2-methoxyethyl)methylamino]methyl]-, ethyl ester
CAS No.:577780-08-6
Molecular Formula:C31H38F2N4O6S
Molecular Weight:632.729
Hs Code.:

3-Thiophenecarboxylic acid,
2-[[(2,6-difluorophenyl)methyl](ethoxycarbonyl)amino]-5-[4-[[(ethylamino)
carbonyl]amino]phenyl]-4-[[(2-methoxyethyl)methylamino]methyl]-, ethyl
ester

Synonyms:

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Chemical Property of 3-Thiophenecarboxylic acid, 2-[[(2,6-difluorophenyl)methyl](ethoxycarbonyl)amino]-5-[4-[[(ethylamino) carbonyl]amino]phenyl]-4-[[(2-methoxyethyl)methylamino]methyl]-, ethyl ester

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Technology Process of 3-Thiophenecarboxylic acid, 2-[[(2,6-difluorophenyl)methyl](ethoxycarbonyl)amino]-5-[4-[[(ethylamino) carbonyl]amino]phenyl]-4-[[(2-methoxyethyl)methylamino]methyl]-, ethyl ester

There total 1 articles about 3-Thiophenecarboxylic acid, 2-[[(2,6-difluorophenyl)methyl](ethoxycarbonyl)amino]-5-[4-[[(ethylamino) carbonyl]amino]phenyl]-4-[[(2-methoxyethyl)methylamino]methyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 577780-07-5
ethyl 5-(4-aminophenyl)-2-[(2,6-difluorobenzyl)(ethoxycarbonyl)amino]-4-{[(2-methoxyethyl)(methyl)amino]methyl}thiophene-3-carboxylate

: 109-90-0
ethyl isocyanate

: 577780-08-6
2-[N-(2,6-difluorobenzyl)-N-ethoxycarbonyl]amino-4-[N-(2-methoxyethyl)-N-methylaminomethyl]-5-[4-(ethylaminocarbonyl)aminophenyl]thiophene-3-carboxylic acid ethyl ester

Guidance literature:: With pyridine; at 0 - 20 ℃; for 18h;

Reference yield: 96.0%

: 577780-08-6
2-[N-(2,6-difluorobenzyl)-N-ethoxycarbonyl]amino-4-[N-(2-methoxyethyl)-N-methylaminomethyl]-5-[4-(ethylaminocarbonyl)aminophenyl]thiophene-3-carboxylic acid ethyl ester

: N-[4-(3-[4-((benzyloxy)phenyl)]-1-(2,6-difluorobenzyl)-5-{[2-methoxyethyl(methyl)amino]methyl}-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl]-N'-ethylurea

Guidance literature:: p-benzyloxyaniline; With dimethyl aluminium chloride; In hexane; dichloromethane; at 0 - 20 ℃; for 1h;

2-[N-(2,6-difluorobenzyl)-N-ethoxycarbonyl]amino-4-[N-(2-methoxyethyl)-N-methylaminomethyl]-5-[4-(ethylaminocarbonyl)aminophenyl]thiophene-3-carboxylic acid ethyl ester; In hexane; dichloromethane; at 20 ℃; for 16h;

Reference yield: 92.0%

: 577780-08-6
2-[N-(2,6-difluorobenzyl)-N-ethoxycarbonyl]amino-4-[N-(2-methoxyethyl)-N-methylaminomethyl]-5-[4-(ethylaminocarbonyl)aminophenyl]thiophene-3-carboxylic acid ethyl ester

: N-[4-(3-(4-nitrophenyl)-1-(2,6-difluorobenzyl)-5-{[2-methoxyethyl(methyl)amino]methyl}-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl]-N'-ethylurea

Guidance literature:: 4-nitro-aniline; With dimethyl aluminium chloride; In hexane; dichloromethane; at 20 ℃; for 1h;

2-[N-(2,6-difluorobenzyl)-N-ethoxycarbonyl]amino-4-[N-(2-methoxyethyl)-N-methylaminomethyl]-5-[4-(ethylaminocarbonyl)aminophenyl]thiophene-3-carboxylic acid ethyl ester; In hexane; dichloromethane; at 20 ℃; for 16h;