1H-Pyrrolo[3,4-c]pyridine-1,3(2H)-dione, 2-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-4-methoxy-6-methyl-

Base Information

Chemical Name:1H-Pyrrolo[3,4-c]pyridine-1,3(2H)-dione, 2-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-4-methoxy-6-methyl-
CAS No.:578742-19-5
Molecular Formula:C22H26N4O4
Molecular Weight:410.46600
Hs Code.:

Synonyms:2-[2-Hydroxy-3-(4-phenyl-piperazin-1-yl)-propyl]-4-methoxy-6-methyl-pyrrolo[3,4-c]pyridine-1,3-dione;4-methoxy-2-[2-hydroxy-3-(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[,4-c]pyridine;

Suppliers and Price of 1H-Pyrrolo[3,4-c]pyridine-1,3(2H)-dione, 2-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-4-methoxy-6-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrrolo[3,4-c]pyridine-1,3(2H)-dione, 2-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-4-methoxy-6-methyl-

Chemical Property:

Melting Point:190-192 °C(Solv: ethanol (64-17-5))
Boiling Point:631.1±55.0 °C(Predicted)
PSA：86.21000
Density:1.295±0.06 g/cm3(Predicted)
LogP:1.11850

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[3,4-c]pyridine-1,3(2H)-dione, 2-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-4-methoxy-6-methyl-

There total 3 articles about 1H-Pyrrolo[3,4-c]pyridine-1,3(2H)-dione, 2-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-4-methoxy-6-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 67568-57-4
3-<4-Phenylpiperazinyl>-2-hydroxypropyl chloride

: 26413-70-7
4-methoxy-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine

: 578742-19-5
4-methoxy-2-[2-hydroxy-3-(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[,4-c]pyridine

Guidance literature:: 4-methoxy-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine; With potassium ethoxide; In ethanol; for 0.25h; Heating;

3-<4-Phenylpiperazinyl>-2-hydroxypropyl chloride; In ethanol; Heating;
DOI:10.1016/S0014-827X(02)01302-2

Reference yield: 61.0%

: 67-56-1
methanol

: 67568-57-4
3-<4-Phenylpiperazinyl>-2-hydroxypropyl chloride

: 40107-91-3
4-chloro-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine

: 578742-19-5
4-methoxy-2-[2-hydroxy-3-(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[,4-c]pyridine

Guidance literature:: methanol; 4-chloro-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine; With sodium methylate; for 0.25h; Heating;

3-<4-Phenylpiperazinyl>-2-hydroxypropyl chloride; In methanol; for 10h; Heating;
DOI:10.1016/S0014-827X(02)01302-2

Reference yield:

: 26413-70-7
4-methoxy-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine

: 578742-19-5
4-methoxy-2-[2-hydroxy-3-(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[,4-c]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / K₂CO₃ / 14 h / Heating

2: 51 percent / ethanol / 1 h / Heating

With potassium carbonate; In ethanol;
DOI:10.1016/S0014-827X(02)01302-2