Carbonochloridic acid, 2-phenylethyl ester

Base Information

• Chemical Name: Carbonochloridic acid, 2-phenylethyl ester
• CAS No.: 57913-41-4
• Molecular Formula: C9H9ClO2
• Molecular Weight: 184.622
• Mol file: 57913-41-4.mol

Synonyms:

Chemical Property of Carbonochloridic acid, 2-phenylethyl ester

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbonochloridic acid, 2-phenylethyl ester

There total 6 articles about Carbonochloridic acid, 2-phenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

phosgene (75-44-5) + 2-phenylethanol (60-12-8) → 2-phenylethyl chloroformate (57913-41-4)

Guidance literature:

In diethyl ether; at 5 - 8 ℃; for 3h;

Reference yield: 85.0%

bis(trichloromethyl) carbonate (32315-10-9) + 2-phenylethanol (60-12-8) → 2-phenylethyl chloroformate (57913-41-4)

Guidance literature:

bis(trichloromethyl) carbonate; With pyridine; In toluene; at 0 ℃; for 3h;

2-phenylethanol; In toluene; at 20 ℃; for 17h;

DOI:10.1016/S0040-4020(02)00112-6

Reference yield:

2-phenylethanol (60-12-8) + triethylamine (121-44-8) → 2-phenylethyl chloroformate (57913-41-4)

Guidance literature:

2-phenylethanol; With bis(trichloromethyl) carbonate; In dichloromethane; at -20 ℃; for 0.166667h; Inert atmosphere;

triethylamine; In dichloromethane; at -20 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.bmc.2019.02.023

upstream raw materials:

phosgene

2-phenylethanol

bis(trichloromethyl) carbonate

triethylamine

Downstream raw materials:

diphenethyl carbonate

1-phenethyloxycarbonyl-4-(benzyloxycarbonyl)azetidin-2-one

2-phenylethyl {4-[({[(Z)-cyano(phenyl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}carbamate

N-(2-phenylethoxycarbonyl) hydroxylamine

Refernces

• 1、 Chang, Sukbok,Jung, Hoimin,Kim, Dongwook,Lee, Jeonghyo,Lee, Jia,Park, Juhyeon. "Versatile Cp*Co(III)(LX) Catalyst System for Selective Intramolecular C-H Amidation Reactions". supporting information. p. 12324 - 12332. Retrieved 2020/08/06.
• 2、 Bibi, David,Mawasi, Hafiz,Nocentini, Alessio,Supuran, Claudiu T.,Wlodarczyk, Bogdan,Finnell, Richard H.,Bialer, Meir. "Design and Comparative Evaluation of the Anticonvulsant Profile, Carbonic-Anhydrate Inhibition and Teratogenicity of Novel Carbamate Derivatives of Branched Aliphatic Carboxylic Acids with 4-Aminobenzensulfonamide". . p. 1972 - 1982. Retrieved 2017/07/17.