69240-96-6

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-(2-chloro-3-hydroxyphenyl)is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the development of new drugs and medications.
Used in Organic Chemical Production:
Ethanone, 1-(2-chloro-3-hydroxyphenyl)is also utilized in the production of organic chemicals, where its specific properties contribute to the formation of desired chemical products.
Used as a Reagent in Chemical Reactions:
Ethanone, 1-(2-chloro-3-hydroxyphenyl)serves as a reagent in various chemical reactions, facilitating specific transformations and processes in the synthesis of different chemical entities.
Used in Cosmetics Industry:
Due to its specific chemical properties, Ethanone, 1-(2-chloro-3-hydroxyphenyl)may find applications in the cosmetics industry, potentially contributing to the development of new cosmetic products.
Used in Agriculture:
Ethanone, 1-(2-chloro-3-hydroxyphenyl)may also have applications in agriculture, where its unique properties could be harnessed for various agricultural purposes, such as in the development of agrochemicals or as a component in fertilizers.

Upstream product

• 54881-49-1 2-chloro-3-methoxy benzaldehyde 
• 1307255-36-2 1-(2-chloro-3-methoxyphenyl)ethanol 
• 1307255-37-3 1-(2-chloro-3-methoxyphenyl)ethanone 
• 121-71-1 3-Hydroxyacetophenone 

Downstream Products

• 959999-74-7 1,1-dimethylethyl 4-[(3-acetyl-2-chlorophenyl)oxy]-1-piperidinecarboxylate 
• 1307255-38-4 tert-butyl (3-endo)-3-(3-acetyl-2-chlorophenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 959999-83-8 C₂₈H₃₀ClF₃N₂O₅SSi 
• 959999-79-2 methyl 3-{[(1R)-1-(2-chloro-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)ethyl]oxy}-5-{6-[(methylsulfonyl)methyl]-1H-benzimidazol-1-yl}-2-thiophenecarboxylate 
• 959999-57-6 methyl 3-[(1R)-1-(3-{[tert-butyl(dimethyl)silyl]oxy}-2-chlorophenyl)ethoxy]-5-(6-cyano-1H-benzimidazol-1-yl)thiophene-2-carboxylate 
• 959999-80-5 methyl 3-[(R)-1-(2-chloro-3-hydroxy-phenyl)-ethoxy]-5-(5-trifluoromethoxy-benzoimidazol-1-yl)-thiophene-2-carboxylate 
• 959999-76-9 Methyl 3-{[(1R)-1-(2-chloro-3-hydroxyphenyl)ethyl]oxy}-5-(6-[(methylsulfonyl)methyl]-1H-benzimidazol-1-yl]-2-thiophenecarboxylate 
• 960000-98-0 methyl 5-(5-chloro-6-fluoro-1H-benzimidazol-1-yl)-3-{[(1R)-1-(2-chloro-3-hydroxyphenyl)ethyl]oxy}-2-thiophenecarboxylate 
• 960001-03-0 E-Methyl 5-(6-chloro-5-fluoro-1H-benzimidazol-1-yl)-3-{[(1R)-1-{2-chloro-3-hydroxyphenyl)ethyl]oxy}-2-thiophenecarboxylate 
• 960001-06-3 methyl 3-(((1R)-1-(2-chloro-3-hydroxyphenyl)ethyl)oxy)-5-(5,6-dichloro-1H-benzimidazol-1-yl)-2-thiophenecarboxylate 
• 959999-53-2 methyl 5-(6-cyano-1H-benzimidazol-1-yl)-3-((R)-1-(2-chloro-3-hydroxy-phenyl)-ethoxy)-2-thiophenecarboxylate 
• 959999-51-0 methyl 5-(5-chloro-1H-benzimidazol-1-yl)-3-{[(1R)-1-(2-chloro-3-hydroxyphenyl)ethyl]oxy}-2-thiophenecarboxylate 
• 959999-73-6 1,1-dimethylethyl 4-({2-chloro-3-[(1S)-1-hydroxyethyl]phenyl}oxy)-1-piperidinecarboxylate 

Relevant academic research and scientific papers

Ammonium Salt-Catalyzed Highly Practical Ortho-Selective Monohalogenation and Phenylselenation of Phenols: Scope and Applications

An ortho-selective ammonium chloride salt-catalyzed direct C-H monohalogenation of phenols and 1,1′-bi-2-naphthol (BINOL) with 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) as the chlorinating agent has been developed. The catalyst loading was low (down to 0.01 mol %) and the reaction conditions were very mild. A wide range of substrates including BINOLs were compatible with this catalytic protocol. Chlorinated BINOLs are useful synthons for the synthesis of a wide range of unsymmetrical 3-aryl BINOLs that are not easily accessible. In addition, the same catalytic system can facilitate the ortho-selective selenylation of phenols.

SMYD INHIBITORS

The present disclosure provides carboxamides and sulfonamides having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, Y, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.

8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE

Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof (In the formula, A represents a group that is represented by formula (A-1); R1a and R1b may be the same or different and each independently represents a C1-6 alkyl group which may be substituted by one to three halogen atoms; m and n each independently represents an integer of 0-5; X1 represents a hydroxyl group or an aminocarbonyl group; Z1 represents a single bond or the like; and R2 represents an optionally substituted C1-6 alkyl group, an optionally substituted C6-10 aryl group or the like.)

Facile p-toluenesulfonic acid-promoted para-selective monobromination and chlorination of phenol and analogues

para-Regioselective bromination of phenol and analogues, promoted by p-toluenesulfonic acid, is achieved in high to excellent yields at room temperature with N-bromosuccinimide. Chlorination with N-chlorosuccinimide and catalysed by p-toluenesulfonic acid also gives para-chlorinated phenol analogues in good yields at room temperature. para-Bromination of phenol, promoted by p-toluenesulfonic acid, is achieved in excellent yields at room temperature with N-bromosuccinimide. p-Toluenesulfonic acid is also effective as a promoter of para-chlorination with N-chlorosuccinimide.