7-Fluoro-4-(4-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

Base Information

Chemical Name:7-Fluoro-4-(4-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[3,4-b]indole
CAS No.:58039-25-1
Molecular Formula:C16H12F2N2
Molecular Weight:270.281
Hs Code.:
ChEMBL ID:CHEMBL1188693
DSSTox Substance ID:DTXSID30505679
Wikidata:Q82360952

Synonyms:58039-25-1;SCHEMBL618810;CHEMBL1188693;DTXSID30505679;PBUHAWCPUJZXSL-UHFFFAOYSA-N;7-Fluoro-4-(4-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[3,4-b]indole;7-Fluoro-4-(p-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

Suppliers and Price of 7-Fluoro-4-(4-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-Fluoro-4-(4-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:270.09685472
Heavy Atom Count:20
Complexity:356

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2=C(CN1)N(C3=C2C=C(C=C3)F)C4=CC=C(C=C4)F

Technology Process of 7-Fluoro-4-(4-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

There total 4 articles about 7-Fluoro-4-(4-fluorophenyl)-1,2,3,4-tetrahydropyrrolo[3,4-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58039-19-3
7-fluoro-4-(p-fluorophenyl)-2-carbethoxy-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

: 58039-25-1
7-fluoro-4-(4-fluorophenyl)-1,2,3,4-tetrahydropyrrolo<3,4-b>indole

Guidance literature:: With potassium hydroxide; In ethanol; water; for 18h; Yield given; Heating;
DOI:10.1021/jm00180a030

Reference yield:

: 823-85-8
4-fluorophenyhydrazine hydrochloride

: 58039-25-1
7-fluoro-4-(4-fluorophenyl)-1,2,3,4-tetrahydropyrrolo<3,4-b>indole

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sodium acetate, 2.) 85percent H₃PO₄ / 1.) water, 20 min, 2.) RT, 1 h

2: 60 percent / Cu₂Br₂, Na₂CO₃, N-methylpyrrolidinone / 4 h / Heating

3: KOH / ethanol; H₂O / 18 h / Heating

With 1-methyl-pyrrolidin-2-one; copper(I) bromide; potassium hydroxide; phosphoric acid; sodium acetate; sodium carbonate; In ethanol; water;
DOI:10.1021/jm00180a030

Reference yield:

: 58039-18-2
7-fluoro-2-carbethoxy-1,2,3,4-tetrahydropyrrolo[3,4-b]indole

: 58039-25-1
7-fluoro-4-(4-fluorophenyl)-1,2,3,4-tetrahydropyrrolo<3,4-b>indole

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / Cu₂Br₂, Na₂CO₃, N-methylpyrrolidinone / 4 h / Heating

2: KOH / ethanol; H₂O / 18 h / Heating

With 1-methyl-pyrrolidin-2-one; copper(I) bromide; potassium hydroxide; sodium carbonate; In ethanol; water;
DOI:10.1021/jm00180a030