1-Benzyl-2-methylbenzimidazole

Base Information

• Chemical Name: 1-Benzyl-2-methylbenzimidazole
• CAS No.: 5805-83-4
• Molecular Formula: C15H14N2
• Molecular Weight: 222.29
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID501323062
• Nikkaji Number: J1.043.152B
• ChEMBL ID: CHEMBL1507048
• Mol file: 5805-83-4.mol

Synonyms:1-benzyl-2-methylbenzimidazole;CHEMBL1507048;1-Benzyl-2-methyl-1H-benzimidazole;1-Benzyl-2-methyl-1H-benzoimidazole;1-benzyl-2-methyl-1H-1,3-benzodiazole;Cambridge id 5325330;MLS001202890;SCHEMBL231295;UFSXKKJZEMLAJF-UHFFFAOYSA-N;DTXSID501323062;HMS2822F07;BDBM50566084;AKOS000546994;WAY-270724;UPCMLD0ENAT5444933:001;5805-83-4;SMR000504767;SR-01000389017;SR-01000389017-1;BRD-K32730123-001-07-6;Z26334200

Chemical Property of 1-Benzyl-2-methylbenzimidazole

Chemical Property:

• PSA: 17.82000
• LogP: 3.39300
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 222.115698455
• Heavy Atom Count: 17
• Complexity: 247

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=CC=CC=C2N1CC3=CC=CC=C3

Technology Process of 1-Benzyl-2-methylbenzimidazole

There total 30 articles about 1-Benzyl-2-methylbenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-benzyl-N'-(2-bromophenyl)acetimidamide (444995-71-5) → 1-benzyl-2-methylbenzimidazole (5805-83-4)

Guidance literature:

With copper(II) oxide; potassium hydroxide; In dimethyl sulfoxide; at 110 ℃; for 6h;

DOI:10.1021/jo901813g

Reference yield: 94.0%

2-Methyl-1H-benzimidazole (615-15-6) + benzyl chloride (100-44-7) → 1-benzyl-2-methylbenzimidazole (5805-83-4)

Guidance literature:

With triethanolamine; at 20 ℃; for 0.0833333h; Sonication; Green chemistry;

Reference yield: 90.0%

2-Methyl-1H-benzimidazole (615-15-6) + benzyl bromide (100-39-0) → 1-benzyl-2-methylbenzimidazole (5805-83-4)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 0.166667h; Micellar solution;

DOI:10.1016/j.tet.2018.08.029

upstream raw materials:

2-Methyl-1H-benzimidazole

benzyl chloride

4-benzylidene-2-methyl-2-oxazolin-5-one

N-benzyl-1,2-phenylenediamine

Downstream raw materials:

1-benzyl-1H-benzo[d]imidazole-2-carbaldehyde

1-benzyl-2-iodo-1H-benzo[d]imidazole

Refernces

• 1、 Ahmad, Matloob,Ashfaq, Usman Ali,Khan, Imran Ahmad,Sultan, Sadia,Zaki, Magdi E. A.. "Discovery of amide-functionalized benzimidazolium salts as potent α-glucosidase inhibitors". . . Retrieved 2021/08/16.
• 2、 Kumar, Gulshan,Shankar, Ravi,Singh, Davinder,Tali, Javeed Ahmad. "Metal-free oxidative decarbonylative halogenation of fused imidazoles". . p. 20551 - 20555. Retrieved 2021/11/23.