4-HYDROXY-2-CHLOROBIPHENYL

Base Information

• Chemical Name: 4-HYDROXY-2-CHLOROBIPHENYL
• CAS No.: 23719-22-4
• Molecular Formula: C₁₂H₉ClO
• Molecular Weight: 204.656
• Hs Code.: 2907199090
• Mol file: 23719-22-4.mol

Synonyms:4-Biphenylol,2-chloro- (8CI); Phenol, o-(p-chlorophenyl)- (6CI,7CI); 2-Chloro-4-biphenylol;2-Chloro-4-hydroxybiphenyl; 4-Hydroxy-2-chlorobiphenyl

Chemical Property of 4-HYDROXY-2-CHLOROBIPHENYL

Chemical Property:

• Boiling Point: 315.4°Cat760mmHg
• PKA: 8.91±0.18(Predicted)
• Flash Point: 144.6°C
• PSA: 20.23000
• Density: 1.239g/cm³
• LogP: 3.71260

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXY-2-CHLOROBIPHENYL

There total 3 articles about 4-HYDROXY-2-CHLOROBIPHENYL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4-bromo-3-chlorophenol (13631-21-5) + phenylboronic acid (98-80-6) → 2-Chloro-4-bisphenylol (23719-22-4)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 95 ℃;

DOI:10.1016/S0968-0896(03)00303-1

Reference yield: 52.0%

3,4-dichlorophenol (95-77-2) + phenylboronic acid (98-80-6) → 2-Chloro-4-bisphenylol (23719-22-4)

Guidance literature:

With potassium carbonate; In water; N,N-dimethyl-formamide; at 27 ℃; for 8h; under 760.051 Torr; Sealed tube; Inert atmosphere; Irradiation;

DOI:10.1039/c9ta13801c

Reference yield:

→ 2-Chloro-4-bisphenylol (23719-22-4)

Guidance literature:

o-Chloro-p-anisidin, Benzol, Amylnitrit, Essigsaeure, BBr3;

upstream raw materials:

4-bromo-3-chlorophenol

phenylboronic acid

3,4-dichlorophenol

Downstream raw materials:

(2R)-2-{3-[3-chloro-(4-phenyl)phenyl]propyl}-N₁-[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]-(N₄-3-propenyloxy)butanediamide

tert-butyl (3R,5E)-6-[(3-chloro-4-phenyl)phenyl]-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hex-5-enoate

tert-butyl (3R)-6-[(3-chloro-4-phenyl)phenyl]-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hexanoate

(3R)-6-[3-chloro-(4-phenyl)phenyl]-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hexanoic acid

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