1-(4-Fluorobenzyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-4(1H)-one

Base Information

Chemical Name:1-(4-Fluorobenzyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-4(1H)-one
CAS No.:58536-94-0
Molecular Formula:C15H13FN4O
Molecular Weight:284.293
Hs Code.:
European Community (EC) Number:664-858-3
Wikidata:Q107140080

Synonyms:1-(4-Fluorobenzyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-4(1H)-one;58536-94-0;SCHEMBL7915358;XAYODJPLXQOKKN-UHFFFAOYSA-N;AKOS024324077;1-(4'-fluorobenzyl)-2-methylamino-pyrido[2,3-d]pyrimidin-4(1H)-one

Suppliers and Price of 1-(4-Fluorobenzyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-4(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-Fluorobenzyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-4(1H)-one

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:284.10733921
Heavy Atom Count:21
Complexity:420

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC1=NC(=O)C2=C(N1CC3=CC=C(C=C3)F)N=CC=C2

Technology Process of 1-(4-Fluorobenzyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-4(1H)-one

There total 8 articles about 1-(4-Fluorobenzyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 58537-02-3
2-(4-fluorophenyl)methylamino-N-(methylamino)(methylthio)methylene-3-pyridinecarboxamide

: 58536-94-0
1-<(4-fluorophenyl)methyl>-2-methylaminopyrido<2,3-d>pyrimidin-4(1H)-one

Guidance literature:: In diethylene glycol dimethyl ether; for 2.5h; Heating;

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 58536-94-0
1-<(4-fluorophenyl)methyl>-2-methylaminopyrido<2,3-d>pyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1) potassium carbonate, 2) Cu / 1) water, RT, 2) dimethylformamide, reflux, 8 h

2: 62 percent / sodium carbonate / H₂O; benzene / 18 h / Ambient temperature

3: 75 percent / sodium carbonate / acetonitrile / 1 h / Heating

4: 70 percent / bis-(2-methoxy-ethyl) ether / 2.5 h / Heating

With copper; sodium carbonate; potassium carbonate; In diethylene glycol dimethyl ether; water; acetonitrile; benzene;

Reference yield:

: 97484-91-8
2-<(4-fluorophenyl)methylamino>-3-pyridinecarboxylic acid

: 58536-94-0
1-<(4-fluorophenyl)methyl>-2-methylaminopyrido<2,3-d>pyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / sodium carbonate / H₂O; benzene / 18 h / Ambient temperature

2: 75 percent / sodium carbonate / acetonitrile / 1 h / Heating

3: 70 percent / bis-(2-methoxy-ethyl) ether / 2.5 h / Heating

With sodium carbonate; In diethylene glycol dimethyl ether; water; acetonitrile; benzene;