2-(4-Hydroxyphenyl)-N-(4-methylphenyl)acetamide

Base Information

Chemical Name:2-(4-Hydroxyphenyl)-N-(4-methylphenyl)acetamide
CAS No.:58609-19-1
Molecular Formula:C15H15NO2
Molecular Weight:241.28500
Hs Code.:
DSSTox Substance ID:DTXSID90564964
Wikidata:Q82449868

Synonyms:2-(4-Hydroxyphenyl)-N-(4-methylphenyl)acetamide;58609-19-1;SCHEMBL2456637;DTXSID90564964;AKOS017179048

Suppliers and Price of 2-(4-Hydroxyphenyl)-N-(4-methylphenyl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of 2-(4-Hydroxyphenyl)-N-(4-methylphenyl)acetamide

Chemical Property:

Melting Point:144 °C
Boiling Point:490.5±33.0 °C(Predicted)
PSA：49.33000
Density:1.219±0.06 g/cm3(Predicted)
LogP:2.95480
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:241.110278721
Heavy Atom Count:18
Complexity:264

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)NC(=O)CC2=CC=C(C=C2)O

Technology Process of 2-(4-Hydroxyphenyl)-N-(4-methylphenyl)acetamide

There total 10 articles about 2-(4-Hydroxyphenyl)-N-(4-methylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 349627-93-6
2-(4-methoxyphenyl)-N-(p-tolyl)acetamide

: 58609-19-1
4-<(p-toluidylcarbonyl)methyl>phenol

Guidance literature:: With boron tribromide; In dichloromethane;

Reference yield:

: 156-38-7
4-hydroxyphenylacetate

: 106-49-0,12221-03-3
p-toluidine

: 58609-19-1
4-<(p-toluidylcarbonyl)methyl>phenol

Guidance literature:: With thionyl chloride; Yield given. Multistep reaction; 1.) reflux, 30 min, 2.) xylene, reflux, 3 h;
DOI:10.1021/jm00106a041

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 58609-19-1
4-<(p-toluidylcarbonyl)methyl>phenol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jacs.5b01926