7-Methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-6-carbonitrile

Base Information

Chemical Name:7-Methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-6-carbonitrile
CAS No.:58610-63-2
Molecular Formula:C10H8N2O2
Molecular Weight:188.18300
Hs Code.:2933990090
DSSTox Substance ID:DTXSID20448384
Mol file:58610-63-2.mol

Synonyms:58610-63-2;7-Methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-6-carbonitrile;1,2,3,5-Tetrahydro-7-methyl-1,5-dioxo-6-indolizinecarbonitrile;7-methyl-1,5-dioxo-2,3-dihydroindolizine-6-carbonitrile;SCHEMBL5960253;DTXSID20448384;MFCD00192478;7-METHYL-1,5-DIOXO-1,2,3,5-TETRAHYDRO-INDOLIZINE-6-CARBONITRILE;AKOS006272186;SY288183;CS-0130175;FT-0675030;E88077

Suppliers and Price of 7-Methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-6-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
1,2,3,5-Tetrahydro-7-methyl-1,5-dioxo-6-indolizinecarbonitrile
5mg
$ 460.00

TRC
1,2,3,5-Tetrahydro-7-methyl-1,5-dioxo-6-indolizinecarbonitrile
100mg
$ 150.00

TRC
1,2,3,5-Tetrahydro-7-methyl-1,5-dioxo-6-indolizinecarbonitrile
50mg
$ 90.00

Crysdot
7-Methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-6-carbonitrile 95+%
1g
$ 470.00

American Custom Chemicals Corporation
7-METHYL-1,5-DIOXO-1,2,3,5-TETRAHYDROINDOLIZINE-6-CARBONITRILE 95.00%
5MG
$ 501.26

Alichem
7-Methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-6-carbonitrile
1g
$ 376.32

Abosyn
7-methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-6-carbonitrile 95%-98%
1g
$ 980.00

aablocks
7-Methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-6-carbonitrile
50mg
$ 250.00

aablocks
7-Methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-6-carbonitrile
100mg
$ 315.00

aablocks
7-Methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-6-carbonitrile
250mg
$ 535.00

Total 14 raw suppliers

Chemical Property of 7-Methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-6-carbonitrile

Chemical Property:

Melting Point:>198°C (dec.)
Boiling Point:450.6±35.0 °C(Predicted)
PKA:-3.91±0.60(Predicted)
PSA：62.86000
Density:1.37±0.1 g/cm3(Predicted)
LogP:0.61478
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:-0.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:188.058577502
Heavy Atom Count:14
Complexity:448

Purity/Quality:

99.5% ^*data from raw suppliers

1,2,3,5-Tetrahydro-7-methyl-1,5-dioxo-6-indolizinecarbonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=O)N2CCC(=O)C2=C1)C#N
Uses 7-METHYL-1,5-DIOXO-1,2,3,5-TETRAHYDRO-INDOLIZINE-6-CARBONITRILE is an intermediate in the preparation of Camptothecin derivatives, for their therapeutic use as antitumor agents.

Technology Process of 7-Methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-6-carbonitrile

There total 4 articles about 7-Methyl-1,5-dioxo-1,2,3,5-tetrahydroindolizine-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.8%

: 73427-92-6
methyl 6-cyano-1-hydroxy-7-methyl-5-oxo-3,5-dihydroindolizine-2-carboxylate

: 58610-63-2
6-cyano-7-methyl-1,5-dioxo-Δ⁶⁽⁸⁾-tetrahydroindolizine

Guidance literature:: With hydrogenchloride; acetic acid; at 100 ℃; for 2h;

Reference yield: 89.0%

: 2-(methoxycarbonyl)-6-cyano-7-methyl-1,5-dioxo-Δ⁶⁽⁸⁾-tetrahydroindolizine

: 58610-63-2
6-cyano-7-methyl-1,5-dioxo-Δ⁶⁽⁸⁾-tetrahydroindolizine

Guidance literature:: With hydrogenchloride; In acetic acid; for 2h; Heating;
DOI:10.1021/jm00179a016

Reference yield:

: 58610-61-0
ethyl 5-cyano-4-methyl-6-oxo-1, 6-dihydropyridine-2-carboxylate

: 58610-63-2
6-cyano-7-methyl-1,5-dioxo-Δ⁶⁽⁸⁾-tetrahydroindolizine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) K₂CO₃ / 1.) DMF, 45 deg C, 2.) DMF, 45 deg C, 40 h

2: 89 percent / conc. HCl / acetic acid / 2 h / Heating

With hydrogenchloride; potassium carbonate; In acetic acid;
DOI:10.1021/jm00179a016