2-(methoxymethoxy)benzoic Acid

Base Information

• Chemical Name: 2-(methoxymethoxy)benzoic Acid
• CAS No.: 5876-91-5
• Molecular Formula: C9H10O4
• Molecular Weight: 182.176
• DSSTox Substance ID: DTXSID10446016
• Nikkaji Number: J1.324.264J
• Wikidata: Q82264574
• Mol file: 5876-91-5.mol

Synonyms:2-(methoxymethoxy)benzoic Acid;5876-91-5;2-methoxymethoxybenzoic acid;SCHEMBL2290756;DTXSID10446016;ARNVPLFYBZBHPU-UHFFFAOYSA-N;AKOS009075902;FT-0671248

Chemical Property of 2-(methoxymethoxy)benzoic Acid

Chemical Property:

• Melting Point: 42-43 °C
• Boiling Point: 321.7±22.0 °C(Predicted)
• PKA: 3.75±0.10(Predicted)
• PSA: 55.76000
• Density: 1.223±0.06 g/cm3(Predicted)
• LogP: 1.36750
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 182.05790880
• Heavy Atom Count: 13
• Complexity: 169

Purity/Quality:

97% ^*data from raw suppliers

2-(Methoxymethoxy)benzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCOC1=CC=CC=C1C(=O)O

Technology Process of 2-(methoxymethoxy)benzoic Acid

There total 6 articles about 2-(methoxymethoxy)benzoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 2-(methoxymethyloxy)benzoate (27701-23-1) → 2-(methoxymethyloxy)benzoic acid (5876-91-5)

Guidance literature:

With lithium hydroxide; In methanol; water; for 4h; Heating;

DOI:10.1021/jm061068d

Reference yield:

methyl salicylate (119-36-8,8024-54-2) → 2-(methoxymethyloxy)benzoic acid (5876-91-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / benzene

2: aq. KOH

With potassium hydroxide; sodium hydride; In benzene;

DOI:10.1021/ja00751a025

Reference yield:

chloromethyl methyl ether (107-30-2) → 2-(methoxymethyloxy)benzoic acid (5876-91-5)

Guidance literature:

With ethanol; durch Behandeln mit alkoh. Kalilauge;

DOI:10.1359/jbmr.2001.16.5.846

upstream raw materials:

methyl 2-(methoxymethyloxy)benzoate

carbon dioxide

O-methoxymethylphenol

chloromethyl methyl ether

Downstream raw materials:

salicylic acid

N-hydroxysuccinimidyl 2-(methoxymethyloxy)benzoate

3-amino-4-hydroxy-2H-chromen-2-one

1-iodo-2-methoxymethoxybenzene