PIPERIDINE-1-CARBOXAMIDINE

Base Information

• Chemical Name: PIPERIDINE-1-CARBOXAMIDINE
• CAS No.: 4705-39-9
• Molecular Formula: C6H13N3
• Molecular Weight: 127.189
• Mol file: 4705-39-9.mol

Synonyms:1-(aminoiminomethyl);amidinopiperidine;Piperidine-1-carboxamidine;piperidinecarboxamidine;piperidine-1-carboximidic acid amide;piperidine N-carboxamidine;N-amidino piperidine;

Chemical Property of PIPERIDINE-1-CARBOXAMIDINE

Chemical Property:

• Melting Point: 250-252 °C(Solv: ethanol (64-17-5))
• Boiling Point: 202.9±23.0 °C(Predicted)
• PKA: 14.54±0.20(Predicted)
• PSA: 53.11000
• Density: 1.21±0.1 g/cm3(Predicted)
• LogP: 1.10370

Purity/Quality:

98% ^*data from raw suppliers

Piperidine-1-carboxamidine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PIPERIDINE-1-CARBOXAMIDINE

There total 17 articles about PIPERIDINE-1-CARBOXAMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

piperidine (110-89-4) + 4-benzyl-3,5-dimethyl-1H-pyrazole-1-carboximidamide hydrochloride → piperidine-1-carboxamidine (4705-39-9)

Guidance literature:

With triethylamine; In acetonitrile; at 60 ℃; for 24h;

DOI:10.1016/S0040-4039(01)02403-0 DOI:10.1055/s-2006-926284

Reference yield: 90.0%

piperidine-1-carboxamidinium sulfate (94052-13-8) → piperidine-1-carboxamidine (4705-39-9)

Guidance literature:

With sodium; In ethanol; at 20 ℃; for 0.5h;

DOI:10.5560/ZNB.2012-0108

Reference yield: 86.0%

piperidine (110-89-4) + polystyrene-bound 3,5-dimethyl-1H-pyrazole-1-carboxamidine hydrochloride, <= 1.8 mmol active pyrazole-1-carboxamidine groups per gram resin → piperidine-1-carboxamidine (4705-39-9)

Guidance literature:

With triethylamine; In dichloromethane; at 60 ℃; for 0.0833333h; microwave irradiation;

DOI:10.1055/s-2006-926284

upstream raw materials:

piperidine

CYANAMID

piperidinium nitrate

piperidinium hydrogen sulfate

Downstream raw materials:

N-(4-chloro-phenyl)-N'-(piperidine-1-carboximidoyl)-thiourea

2-(piperidin-1-yl)thiazole-4(5H)-one

2-(6-oxo-4-phenyl-2-(piperidin-1-yl)-1,6-dihydropyrimidin-5-yl)pentanoic acid

C₃₀H₂₇N₇

Refernces

• 1、 Guo, Dexiang,Liu, Yajing,Li, Ting,Wang, Nan,Zhai, Xin,Hu, Chun,Gong, Ping. "Synthesis and antitumor activities of a new series of 4,5-dihydro-1H- thiochromeno[4,3-d]pyrimidine derivatives". experimental part. p. 347 - 351. Retrieved 2012/08/08.
• 2、 Zhang, Fan,Zhai, Xin,Chen, Li Juan,Qi, Jian Guo,Cui, Bo,Gu, Yu Cheng,Gong, Ping. "Synthesis and cytotoxic activity of 2,5-disubstituted pyrimido[5,4-c] quinoline derivatives". scheme or table. p. 1277 - 1280. Retrieved 2012/01/06.