Carbamic acid, [2-[[[5-chloro-3-(2-chlorophenyl)-1-methyl-1H-indol-2-yl]methyl]amino]-2- oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester, (S)-

Base Information

Chemical Name:Carbamic acid, [2-[[[5-chloro-3-(2-chlorophenyl)-1-methyl-1H-indol-2-yl]methyl]amino]-2- oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester, (S)-
CAS No.:59179-99-6
Molecular Formula:C33H29Cl2N3O3
Molecular Weight:586.518
Hs Code.:

Carbamic acid,
[2-[[[5-chloro-3-(2-chlorophenyl)-1-methyl-1H-indol-2-yl]methyl]amino]-2-
oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester, (S)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [2-[[[5-chloro-3-(2-chlorophenyl)-1-methyl-1H-indol-2-yl]methyl]amino]-2- oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester, (S)-

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Technology Process of Carbamic acid, [2-[[[5-chloro-3-(2-chlorophenyl)-1-methyl-1H-indol-2-yl]methyl]amino]-2- oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester, (S)-

There total 5 articles about Carbamic acid, [2-[[[5-chloro-3-(2-chlorophenyl)-1-methyl-1H-indol-2-yl]methyl]amino]-2- oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.7%

: 1161-13-3
N-Cbz-L-Phe

: 63614-96-0
2-(aminomethyl)-5-chloro-3-(o-chlorophenyl)-1-methylindole

: 59179-99-6
5-chloro-3-(o-chlorophenyl)-1-methyl-2-<α-<(benzyloxycarbonyl)phenylalanyl>amino>methyl>indole

Guidance literature:: With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; a) -20 deg C, 2 h, b) RT, 2 h;
DOI:10.1021/jm00181a013

Reference yield:

: 24107-07-1
ethyl 5-chloro-3-(o-chlorophenyl)-indole-2-carboxylate

: 59179-99-6
5-chloro-3-(o-chlorophenyl)-1-methyl-2-<α-<(benzyloxycarbonyl)phenylalanyl>amino>methyl>indole

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) DMF, RT, 1.5 h, 2.) DMF, RT, overnight

2: 98.5 percent / 86percent KOH / ethanol / 2 h / Heating

3: 1.) SOCl₂, 2.) NH₃ (gas) / 1.) reflux, 3 h, 2.) THF, RT, 3 h

4: LiAlH₄ / diethyl ether / a) RT, 10.5 h, b) reflux, 4 h

5: 90.7 percent / DCC, N-hydroxysuccinimide / dimethylformamide / a) -20 deg C, 2 h, b) RT, 2 h

With potassium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; lithium aluminium tetrahydride; thionyl chloride; ammonia; sodium hydride; dicyclohexyl-carbodiimide; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00181a013

Reference yield:

: 74098-80-9
5-chloro-3-(o-chlorophenyl)-1-methylindole-2-carboxylic acid

: 59179-99-6
5-chloro-3-(o-chlorophenyl)-1-methyl-2-<α-<(benzyloxycarbonyl)phenylalanyl>amino>methyl>indole

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) SOCl₂, 2.) NH₃ (gas) / 1.) reflux, 3 h, 2.) THF, RT, 3 h

2: LiAlH₄ / diethyl ether / a) RT, 10.5 h, b) reflux, 4 h

3: 90.7 percent / DCC, N-hydroxysuccinimide / dimethylformamide / a) -20 deg C, 2 h, b) RT, 2 h

With 1-hydroxy-pyrrolidine-2,5-dione; lithium aluminium tetrahydride; thionyl chloride; ammonia; dicyclohexyl-carbodiimide; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00181a013