1-Methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:1-Methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:59224-74-7
Molecular Formula:C16H17NO
Molecular Weight:239.317
Hs Code.:
DSSTox Substance ID:DTXSID00695672

Synonyms:DTXSID00695672;1-Methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of 1-Methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-(4-METHOXYPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE 95.00%
5MG
$ 497.41

Total 4 raw suppliers

Chemical Property of 1-Methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Melting Point:84-85 °C(Solv: cyclohexane (110-82-7))
Boiling Point:376.4±30.0 °C(Predicted)
PKA:8.97±0.40(Predicted)
PSA：21.26000
Density:1.085±0.06 g/cm3(Predicted)
LogP:3.25910
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:239.131014166
Heavy Atom Count:18
Complexity:274

Purity/Quality:

97% ^*data from raw suppliers

1-(4-METHOXYPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1(C2=CC=CC=C2CCN1)C3=CC=CC=C3

Technology Process of 1-Methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

There total 8 articles about 1-Methoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59224-73-6
1-(4'-methoxylphenyl)-3,4-dihydroisoquinoline

: 59224-74-7
1-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With hydrogen; platinum(IV) oxide; In ethanol; for 10h; under 2792.6 Torr; Yield given;
DOI:10.1021/jm00126a016

Reference yield:

: 6346-07-2
4-methoxy-N-(2-phenylethyl)benzamide

: 59224-74-7
1-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: POCl₃, P₂O₅ / 2 h / Heating

2: H₂ / PtO₂ / ethanol / 10 h / 2792.6 Torr

With hydrogen; phosphorus pentoxide; trichlorophosphate; platinum(IV) oxide; In ethanol;
DOI:10.1021/jm00126a016

Reference yield:

: 139437-83-5
ethyl 1-(4-methoxyphenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 59224-74-7
1-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: ethyl 1-(4-methoxyphenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate; With sodium hydroxide; ethanol; water; at 100 ℃; for 3h;

With potassium hydroxide; ethanol; water; for 64h; Heating / reflux;