Technology Process of 4H-Furo[3,2-b]pyrrole-5-carboxylic acid,
3-(4-chlorophenyl)-4-[2-(4-morpholinyl)ethyl]-2-phenyl-, ethyl ester
There total 6 articles about 4H-Furo[3,2-b]pyrrole-5-carboxylic acid,
3-(4-chlorophenyl)-4-[2-(4-morpholinyl)ethyl]-2-phenyl-, ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 70 percent / NaCO3 / Pd(PPh3)4 / toluene; ethanol / 2 h / 80 °C
2: 87 percent / NBS / acetonitrile / 16 h / 20 °C
3: 48 percent / Na; EtOH / 2 h / 0 °C
4: 64 percent / toluene / 16 h / Heating
5: 82 percent / Na2CO3 / Pd(PPh3)4 / toluene; ethanol
6: 56 percent / NaH; NaI / 16 h / 60 °C
With
N-Bromosuccinimide; ethanol; sodium; sodium hydride; sodium carbonate; sodium iodide;
tetrakis(triphenylphosphine) palladium(0);
In
ethanol; toluene; acetonitrile;
1: Suzuki coupling / 5: Suzuki coupling;
DOI:10.1016/S0040-4039(03)00895-5
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 87 percent / NBS / acetonitrile / 16 h / 20 °C
2: 48 percent / Na; EtOH / 2 h / 0 °C
3: 64 percent / toluene / 16 h / Heating
4: 82 percent / Na2CO3 / Pd(PPh3)4 / toluene; ethanol
5: 56 percent / NaH; NaI / 16 h / 60 °C
With
N-Bromosuccinimide; ethanol; sodium; sodium hydride; sodium carbonate; sodium iodide;
tetrakis(triphenylphosphine) palladium(0);
In
ethanol; toluene; acetonitrile;
4: Suzuki coupling;
DOI:10.1016/S0040-4039(03)00895-5
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 48 percent / Na; EtOH / 2 h / 0 °C
2: 64 percent / toluene / 16 h / Heating
3: 82 percent / Na2CO3 / Pd(PPh3)4 / toluene; ethanol
4: 56 percent / NaH; NaI / 16 h / 60 °C
With
ethanol; sodium; sodium hydride; sodium carbonate; sodium iodide;
tetrakis(triphenylphosphine) palladium(0);
In
ethanol; toluene;
3: Suzuki coupling;
DOI:10.1016/S0040-4039(03)00895-5