6-bromo-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one

Base Information

Chemical Name:6-bromo-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one
CAS No.:59514-19-1
Molecular Formula:C13H12BrNO
Molecular Weight:
Hs Code.:
DSSTox Substance ID:DTXSID501213855

Synonyms:6-bromo-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one;59514-19-1;6-bromo-9-methyl-3,4-dihydro-2H-carbazol-1-one;CHEMBRDG-BB 5130444;6-Bromo-9-methyl-2,3,4,9-tetrahydro-carbazol-1-one;Cambridge id 5130444;6-bromo-9-methyl-1,2,3,4-tetrahydrocarbazol-1-one;SCHEMBL4150768;DTXSID501213855;CCG-18148;STK835327;AKOS000530779;BS-38271;CS-0319745;EU-0040908;AB00074207-01;SR-01000457523;SR-01000457523-1;6-Bromo-2,3,4,9-tetrahydro-9-methyl-1H-carbazol-1-one

Suppliers and Price of 6-bromo-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 6-bromo-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one

Chemical Property:

Vapor Pressure:1.03E-07mmHg at 25°C
XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:277.01023
Heavy Atom Count:16
Complexity:306

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C2=C(C=C(C=C2)Br)C3=C1C(=O)CCC3

Technology Process of 6-bromo-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one

There total 4 articles about 6-bromo-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 59514-18-0
6-bromo-2,3,4,9-tetrahydro-1H-carbazol-1-one

: 74-88-4
methyl iodide

: 59514-19-1
6-bromo-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one

Guidance literature:: 6-bromo-2,3,4,9-tetrahydro-1H-carbazol-1-one; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; at 70 ℃; for 0.5h;
DOI:10.1007/s11178-005-0257-0

Reference yield: 34.0%

: 74-88-4
methyl iodide

: 59514-19-1
6-bromo-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one

Guidance literature:: 6-bromo-2,3,4,9-tetrahydro-1H-carbazol-1-one; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield:

: 876472-33-2
9-acetyl-6-bromo-1,2,3,4-tetrahydrocarbazol-1-one

: 59514-19-1
6-bromo-9-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97 percent / piperidine; K₃PO₄; 2-(di-tert-butylphosphino)biphenyl / Pd₂dba3*CHCl₃ / toluene / 100 °C

2.1: sodium hydride / dimethylformamide / 0.5 h / 0 - 5 °C

2.2: 85 percent / dimethylformamide / 0.5 h / 70 °C

With piperidine; potassium phosphate; sodium hydride; johnphos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In N,N-dimethyl-formamide; toluene;
DOI:10.1007/s11178-005-0257-0