59514-18-0Relevant articles and documents
Tetrahydrocarbazole amides with potent activity against human papillomaviruses
Gudmundsson, Kristjan S.,Boggs, Sharon D.,Sebahar, Paul R.,Richardson, Leah D'Aurora,Spaltenstein, Andrew,Golden, Pamela,Sethna, Phiroze B.,Brown, Kevin W.,Moniri, Kelly,Harvey, Robert,Romines, Karen R.
, p. 4110 - 4114 (2009)
Synthesis of a series of tetrahydrocarbazole amides with potent activity against human papillomaviruses is described. Synthetic approaches allowing for variation of the substitution pattern of the tetrahydrocarbazole and the amide are outlined and resulti
COMPOUNDS FOR THE REDUCTION OF THE DELETERIOUS ACTIVITY OF EXTENDED NUCLEOTIDE REPEAT CONTAINING GENES
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Page/Page column 62; 63, (2020/07/14)
Aspects of the present disclosure include methods of reducing the deleterious impact of a target gene in a cell, such as the deleterious activity of a mutant extended nucleotide repeat (NR) containing target gene in a cell by contacting the cell with an effective amount of a tetrahydrocarbazole compound. The deleterious activity (e.g., toxicity and/or dis-functionality of products encoded thereby) of a mutant extended NR containing target gene may be reduced, e.g., by reducing (and in some instances differentially, including selectively, reducing) the production or activity of toxic expression products (e.g., RNA or protein) encoded by the target gene. Kits and compositions for practicing the subject methods are also provided.
THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION
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Page/Page column 72, (2019/01/17)
Disclosed herein are compounds of formula I: or a salt thereof and compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for treating or preventing a bacterial infection in an anim
