4-Methoxyquinolin-8-amine

Base Information

• Chemical Name: 4-Methoxyquinolin-8-amine
• CAS No.: 59665-93-9
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.19900
• DSSTox Substance ID: DTXSID10483385
• Nikkaji Number: J90.059A
• Wikidata: Q82320668
• Mol file: 59665-93-9.mol

Synonyms:4-methoxyquinolin-8-amine;59665-93-9;8-AMINO-4-METHOXYQUINOLINE;4-Methoxy-quinolin-8-ylamine;SCHEMBL7247375;DTXSID10483385;ILLFDHRDCAUCTG-UHFFFAOYSA-N;MFCD09261105;AKOS006329748;SB67786;AM806224;AS-54793;CS-0150283;FT-0709226;EN300-123713;W10156

Chemical Property of 4-Methoxyquinolin-8-amine

Chemical Property:

• PSA: 48.14000
• LogP: 2.40680
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 174.079312947
• Heavy Atom Count: 13
• Complexity: 174

Purity/Quality:

98% ^*data from raw suppliers

8-Amino-4-methoxyquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C2C=CC=C(C2=NC=C1)N

Technology Process of 4-Methoxyquinolin-8-amine

There total 10 articles about 4-Methoxyquinolin-8-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.7%

4-methoxy-8-nitroquinoline (89770-28-5) → 4-methoxyquinoline-8-amine (59665-93-9)

Guidance literature:

With tris(bipyridine)ruthenium(II) dichloride hexahydrate; ascorbic acid; In methanol; water; at 20 ℃; for 2h; chemoselective reaction; Schlenk technique; Inert atmosphere; Irradiation; Green chemistry;

DOI:10.1021/acs.orglett.9b01205

Reference yield: 65.0%

7-chloro-4-methoxy-quinolin-8-ylamine (1394083-96-5) → 4-methoxyquinoline-8-amine (59665-93-9)

Guidance literature:

With ammonium formate; acetic acid; palladium 10% on activated carbon; In water; for 0.5h; Reflux;

Reference yield:

4-methoxy-8-nitroquinoline (89770-28-5) → 4-methoxyquinoline-8-amine (59665-93-9) + N-(4-methoxyquinolin-8-yl)hydroxylamine

Guidance literature:

With tris(bipyridine)ruthenium(II) dichloride hexahydrate; ascorbic acid; In d⁽⁴⁾-methanol; water-d2; at 20 ℃; for 1.5h; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1021/acs.orglett.9b01205

upstream raw materials:

4-methoxy-8-nitroquinoline

4-chloroquinoline

4-chloro-8-nitroquinoline

4,7-dichloroquinoline

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