5,7-Dimethoxychromone

Base Information

• Chemical Name: 5,7-Dimethoxychromone
• CAS No.: 59887-91-1
• Molecular Formula: C11H10O4
• Molecular Weight: 206.198
• DSSTox Substance ID: DTXSID70495247
• Nikkaji Number: J1.032.930B
• Wikidata: Q82343225
• Mol file: 59887-91-1.mol

Synonyms:5,7-Dimethoxychromone;5,7-dimethoxychromen-4-one;59887-91-1;5,7-Dimethoxy-4H-chromen-4-one;5,7-dimethoxy-4-chromenone;SCHEMBL1472177;DTXSID70495247;5,7-Dimethoxy-4H-1-benzopyran-4-one;EN300-7356591;Z1551916016

Chemical Property of 5,7-Dimethoxychromone

Chemical Property:

• PSA: 48.67000
• LogP: 1.81020
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 206.05790880
• Heavy Atom Count: 15
• Complexity: 274

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C(=O)C=CO2)C(=C1)OC

Technology Process of 5,7-Dimethoxychromone

There total 18 articles about 5,7-Dimethoxychromone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-hydroxy-4,6-dimethoxyacetophenone (90-24-4) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 5,7-dimethoxy-4H-chromen-4-one (59887-91-1)

Guidance literature:

In benzene; at 90 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2018.04.037

Reference yield: 90.0%

→ 5,7-dimethoxy-4H-chromen-4-one (59887-91-1)

Guidance literature:

In benzene; at 90 ℃; Inert atmosphere;

Reference yield: 82.0%

2',4'-dimethoxyacetophenone (829-20-9) + formic acid ethyl ester (109-94-4) → 5,7-dimethoxy-4H-chromen-4-one (59887-91-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.0833333h; Reflux;

DOI:10.1016/j.bmcl.2018.07.031

upstream raw materials:

7-benzyloxy-5-methoxy-chromen-4-one

methanol

5,7-dimethoxy-4-chromanone

2.3-Dihydro-2-hydroxy-5.7-dimethoxy-chromon (II)

Downstream raw materials:

(R)-2,3-dihydro-5,7-dimethoxy-2-phenyl-4H-1-benzopyran-4-one

5-hydroxy-7-methoxyflavonone

pinostrobin

Pinocembrin dimethyl ether