DTNB-NHS

Base Information

• Chemical Name: DTNB-NHS
• CAS No.: 60129-38-6
• Molecular Formula: C22H14N4O12S2
• Molecular Weight: 590.505
• Hs Code.: 29251900
• Mol file: 60129-38-6.mol

Synonyms:5,5'-dithiobis(2-nitrobenzoic acid N-hydroxysuccinimide ester);5,5'-dithiobis(succinimidyl-2-nitrobenzoate);3,3'-Dithiobis[6-nitrobenzoic acid] bis(succinimide) ester;

Chemical Property of DTNB-NHS

Chemical Property:

• PSA: 269.60000
• Density: 1.78
• LogP: 3.66620

Purity/Quality:

98%+ ^*data from raw suppliers

5,5''-dithiobis(2-nitrobenzoicacidSuccinimidyl)ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5,5''-dithiobis(2-nitrobenzoic acid Succinimidyl) ester (CAS# 60129-38-6) is a biofunctionalized nanoprobe for SERS-based immunoassays, acting as a linker for protein and gold nanoparticles. It has also been used as a probe in the detection of tuberculosis antigenic markers.

Technology Process of DTNB-NHS

There total 1 articles about DTNB-NHS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 5,5'-dithiobis-(2-nitrobenzoic acid) (69-78-3) → 5,5'-dithiobis(2-nitrobenzoic acid succinimidyl diester) (60129-38-6)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 25 - 28 ℃; for 2h;

Reference yield: 41.0%

5,5'-dithiobis(2-nitrobenzoic acid succinimidyl diester) (60129-38-6) + 2-[(6-aminohexanoyl)amino]-2-deoxy-D-glucono-δ-lactam (1054644-86-8) → 5-{3-[5-((3R,4R,5R,6R)-4,5-Dihydroxy-6-hydroxymethyl-2-oxo-piperidin-3-ylcarbamoyl)-pentylcarbamoyl]-4-nitro-phenyldisulfanyl}-2-nitro-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester (250737-32-7)

Guidance literature:

In N,N-dimethyl-formamide; at 4 ℃; for 16h;

DOI:10.1002/(sici)1099-0690(199910)1999:10<2593::aid-ejoc2593>3.0.co;2-c

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

5,5'-dithiobis-(2-nitrobenzoic acid)

Downstream raw materials:

5-{3-[5-((3R,4R,5R,6R)-4,5-Dihydroxy-6-hydroxymethyl-2-oxo-piperidin-3-ylcarbamoyl)-pentylcarbamoyl]-4-nitro-phenyldisulfanyl}-2-nitro-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester

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