Ethyl pyrrolidine-2-carboxylate

Base Information

• Chemical Name: Ethyl pyrrolidine-2-carboxylate
• CAS No.: 60169-67-7
• Molecular Formula: C7H13NO2
• Molecular Weight: 143.186
• Hs Code.: 2933998090
• Mol file: 60169-67-7.mol

Synonyms:proline ethyl ester;2-ethoxycarbonylpyrrolidine;ethyl 2-pyrrolidinecarboxylate;pyrrolidine-2-carboxylic acid ethyl ester;1-L-proline acid ethyl ester;

Chemical Property of Ethyl pyrrolidine-2-carboxylate

Chemical Property:

• PSA: 38.33000
• LogP: 0.63030

Purity/Quality:

97% ^*data from raw suppliers

Ethylpyrrolidine-2-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl pyrrolidine-2-carboxylate

There total 11 articles about Ethyl pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 6-ethoxy-5,6-dihydro-4H-1,2-oxazine-3-carboxylate (112135-47-4) → ethyl pyrrolidine-2-carboxylate (60169-67-7)

Guidance literature:

With aluminum amalgam; In tetrahydrofuran; water; for 2.5h;

Reference yield: 85.3%

ethanol (64-17-5) + rac-Pro-OH (609-36-9,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → ethyl pyrrolidine-2-carboxylate (60169-67-7)

Guidance literature:

With thionyl chloride;

DOI:10.1007/BF00768332

Reference yield: 71.0%

ethanol (64-17-5) + L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → ethyl pyrrolidine-2-carboxylate (60169-67-7)

Guidance literature:

With thionyl chloride; for 5h; Heating;

upstream raw materials:

ethanol

L-proline

rac-Pro-OH

methyl pyrrolidine-2-carboxylate

Downstream raw materials:

DL-prolin-(2-amino-ethylamide)

pyrrolidine-2-carboxylic acid amide

1-[2-(3,4-Dimethoxy-phenyl)-acetyl]-pyrrolidine-2-carboxylic acid ethyl ester

?Tyr