H-DL-PRO-NH2

Base Information

• Chemical Name: H-DL-PRO-NH2
• CAS No.: 2812-47-7
• Molecular Formula: C5H10 N2 O
• Molecular Weight: 114.147
• Hs Code.: 2933990090
• Mol file: 2812-47-7.mol

Synonyms:Prolinamide(7CI,8CI); (?à)-2-Pyrrolidinecarboxamide;DL-Proline amide; Pyrrolidine-2-carboxylic acid amide

Chemical Property of H-DL-PRO-NH2

Chemical Property:

• Melting Point: 104 °C
• Boiling Point: 303.6±31.0 °C(Predicted)
• PKA: 16.21±0.20(Predicted)
• PSA: 55.12000
• Density: 1.106
• LogP: 0.25280
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

DL-Prolinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41-51
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: H-DL-PRO-NH2 is a proline derivative used in DNA catalysts for the aldol reaction between a porphyrin-bearing aldehyde and a ketone. A proline derivative used in DNA catalysts for the aldol reaction between a porphyrin-bearing aldehyde and a ketone.

Technology Process of H-DL-PRO-NH2

There total 10 articles about H-DL-PRO-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.5%

→ (2S)-1-[3[2-(1H-indol-5-yl)-5-[[(4S)-4-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl] carbonyl] phenoxy]propyl]-2-pyrrolidine carboxamide + pyrrolidine-2-carboxylic acid amide (2812-47-7)

Guidance literature:

Reference yield: 10.0%

2-(aminocarbonyl)-1-pyrrolidinecarboxylic acid, phenylmethyl ester (93188-01-3,58274-22-9) → tetrahydropyrrolo[1,2-c]imidazol-1,3-dione (5768-79-6,214066-57-6) + pyrrolidine-2-carboxylic acid amide (2812-47-7)

Guidance literature:

With sodium; ammonium chloride; In ammonia;

DOI:10.1039/C39820000639

Reference yield:

2-(aminocarbonyl)-1-pyrrolidinecarboxylic acid, phenylmethyl ester (93188-01-3,58274-22-9) → pyrrolidine-2-carboxylic acid amide (2812-47-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 5h; under 2068.6 Torr;

DOI:10.1016/0040-4020(96)00030-0

upstream raw materials:

ethyl pyrrolidine-2-carboxylate

DL-Pro-NCA

2-(aminocarbonyl)-1-pyrrolidinecarboxylic acid, phenylmethyl ester

pyrrolidine-2-carbonitrile

Downstream raw materials:

N-acetylprolinamide

2-(aminocarbonyl)-1-pyrrolidinecarboxylic acid, phenylmethyl ester

(2R)-2-carbamoyl-pyrrolidine-1-carboxylic acid benzyl ester

Tfa-DL-Pro-NH2