TERT-BUTYL 2-CYCLOHEXYLHYDRAZINECARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 2-CYCLOHEXYLHYDRAZINECARBOXYLATE
• CAS No.: 60295-21-8
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.308
• Hs Code.: 2928000090
• Mol file: 60295-21-8.mol

Synonyms:Trans-4-tert-butoxycarbonylamino-aminocyclohexane;tert-butyl cyclohexylhydrazinocarboxylate;1,1-dimethylethyl 2-cyclohexylhydrazinecarboxylate;tert-butyl 2-cyclohexylhydrazinecarboxylate;tert-butyl 2-cyclohexyl hydrazinecarboxylate;2-cyclohexylhydrazinecarboxylic acid 1,1-dimethylethyl ester;

Chemical Property of TERT-BUTYL 2-CYCLOHEXYLHYDRAZINECARBOXYLATE

Chemical Property:

• Melting Point: 76-77 °C
• PKA: 10.58±0.20(Predicted)
• PSA: 50.36000
• Density: 1.01±0.1 g/cm3(Predicted)
• LogP: 3.13020

Purity/Quality:

99% ^*data from raw suppliers

tert-butyl2-cyclohexylhydrazinecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 2-CYCLOHEXYLHYDRAZINECARBOXYLATE

There total 11 articles about TERT-BUTYL 2-CYCLOHEXYLHYDRAZINECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

t-butoxycarbonylhydrazine (870-46-2) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → N'-cyclohexyl-hydrazine carboxylic acid tert-butyl ester (60295-21-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/jm5004528

Reference yield: 92.0%

tert-butyl 2-cyclohexylidenehydrazine-1-carboxylate (60295-11-6) → N'-cyclohexyl-hydrazine carboxylic acid tert-butyl ester (60295-21-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 50 ℃; under 7600.51 Torr;

Reference yield: 45.0%

cyclohexylamine (108-91-8,157973-60-9) + oxaziridine-2,3,3-tricarboxylic acid 2-tert-butyl ester 3,3-diethyl ester (462100-44-3) → C16H31N3O4 + N'-cyclohexyl-hydrazine carboxylic acid tert-butyl ester (60295-21-8)

Guidance literature:

In toluene; at 20 ℃; for 72h;

DOI:10.1021/ol0474507

upstream raw materials:

tert-butyl 2-cyclohexylidenehydrazine-1-carboxylate

cyclohexylamine

oxaziridine-2,3,3-tricarboxylic acid 2-tert-butyl ester 3,3-diethyl ester

triphenyl(t-butoxycarbonylimino)phosphorane

Downstream raw materials:

diethyl 2-(((1-cyclohexyl-3-methyl-1H-pyrazol-5-yl)amino)methylene)malonate

1-cyclohexyl-3-methyl-1H-pyrazol-5-amine

1,1-dimethylethyl 2-(2-chloro-9-methyl-9H-purin-6-yl)-2-cyclo-hexyl-hydrazine-carboxylate

1,1-dimethylethyl 2-(5-bromo-2-chloro-4-pyrimidinyl)-2-cyclohexylhydrazinecarboxylate

Refernces

• 1、 Sharma, Swagat,Kozek, Krystian A.,Abney, Kristopher K.,Kumar, Sushil,Gautam, Nagsen,Alnouti, Yazen,David Weaver,Hopkins, Corey R.. "Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators". . p. 791 - 796. Retrieved 2019/02/06.
• 2、 -. "PYRAZOLOPYRIMIDINES AS INHIBITORS OF GLUCOCORTICOID RECEPTOR TRANSLOCATION". Paragraph 00475. . Retrieved 2016/08/23.