1-BroMo-2-(2-propen-1-yloxy)-benzene

Base Information

• Chemical Name: 1-BroMo-2-(2-propen-1-yloxy)-benzene
• CAS No.: 60333-75-7
• Molecular Formula: C9H9BrO
• Molecular Weight: 213.074
• Mol file: 60333-75-7.mol

Synonyms:benzene,1-bromo-2-(2-propenyloxy);1-allyloxy-2-bromo-benzene;ortho-allyloxy-bromobenzene;o-allyloxy-bromo-benzene;EINECS 246-754-6;2-bromophenyl 2-propenyl ether;1-bromo-2-(prop-2-enyloxy)benzene;allyl o-bromophenyl ether;allyl (2-bromophenyl) ether;

Chemical Property of 1-BroMo-2-(2-propen-1-yloxy)-benzene

Chemical Property:

• PSA: 9.23000
• LogP: 3.01390
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

1-Bromo-2-(2-propen-1-yloxy)-benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Bromo-2-(2-propen-1-yloxy)-benzene is used as a reagent to produce high yield (97%) 3-methyl-2,3-dihydrobenzofurans through reductive radical cyclization reactions.

Technology Process of 1-BroMo-2-(2-propen-1-yloxy)-benzene

There total 8 articles about 1-BroMo-2-(2-propen-1-yloxy)-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-hydroxybromobenzene (95-56-7) + allyl bromide (106-95-6) → O-allyl-2-bromophenol (60333-75-7)

Guidance literature:

With potassium carbonate; In acetone; for 6h; Heating / reflux;

Reference yield: 93.0%

1-bromo-4-butene (5162-44-7) + 2-hydroxybromobenzene (95-56-7) → O-allyl-2-bromophenol (60333-75-7)

Guidance literature:

With potassium carbonate; In acetone; for 12h; Inert atmosphere; Reflux;

DOI:10.3390/molecules25030602

Reference yield: 85.0%

2-hydroxybromobenzene (95-56-7) → O-allyl-2-bromophenol (60333-75-7)

Guidance literature:

With potassium carbonate; sodium iodide; In acetone; for 5h; Heating;

DOI:10.1021/ol0258029

upstream raw materials:

2-hydroxybromobenzene

allyl bromide

3-chloroprop-1-ene

(Z)-1-bromo-2-(prop-1-en-1-yloxy)benzene

Downstream raw materials:

2-bromo-6-(2-propenyl)phenol

[3-(2-Bromo-phenoxy)-propyl]-dichloro-methyl-silane

Triethoxy-(3-o-bromphenoxypropyl)-silan

3-methyl-2,3-dihydrobenzofuran

Refernces

• 1、 -. "COMPETITIVE AND NONCOMPETITIVE INHIBITORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M5". Paragraph 00404. . Retrieved 2021/11/26.
• 2、 Liu, Ce,Li, Yuke,Shi, Wei-Yu,Ding, Ya-Nan,Zheng, Nian,Liu, Hong-Chao,Liang, Yong-Min. "Palladium-Catalyzed Chemoselective Oxidative Addition of Allyloxy-Tethered Aryl Iodides: Synthesis of Medium-Sized Rings and Mechanistic Studies". supporting information. p. 4311 - 4316. Retrieved 2021/05/26.