N-(2-METHOXY-PHENYL)-FORMAMIDE

Base Information

• Chemical Name: N-(2-METHOXY-PHENYL)-FORMAMIDE
• CAS No.: 23896-88-0
• Molecular Formula: C8H9 N O2
• Molecular Weight: 151.165
• Hs Code.: 2924299090
• Mol file: 23896-88-0.mol

Synonyms:o-Formanisidide(7CI,8CI); 2-Methoxyformanilide; N-Formyl-2-methoxyaniline; NSC 53664

Chemical Property of N-(2-METHOXY-PHENYL)-FORMAMIDE

Chemical Property:

• Vapor Pressure: 0.000186mmHg at 25°C
• Melting Point: 84 °C
• Boiling Point: 328.7°Cat760mmHg
• PKA: 14.37±0.70(Predicted)
• Flash Point: 152.6°C
• PSA: 38.33000
• Density: 1.16g/cm³
• LogP: 1.97240

Purity/Quality:

99% ^*data from raw suppliers

ORTHO-FORMANISIDIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of N-(2-METHOXY-PHENYL)-FORMAMIDE

There total 30 articles about N-(2-METHOXY-PHENYL)-FORMAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

formic acid (64-18-6) + 2-methoxy-phenylamine (90-04-0) → formic acid o-anisidide (23896-88-0)

Guidance literature:

With sodium formate; at 20 ℃; for 6h; Neat (no solvent);

DOI:10.1016/j.tetlet.2010.02.119

Reference yield: 99.0%

4-chlorophenyl formate (1988-22-3) + 2-methoxy-phenylamine (90-04-0) → formic acid o-anisidide (23896-88-0)

Guidance literature:

In neat (no solvent); at 20 ℃; for 1h;

DOI:10.1080/00397911.2016.1255334

Reference yield: 99.0%

carbon dioxide (124-38-9,18923-20-1) + 2-methoxy-phenylamine (90-04-0) → formic acid o-anisidide (23896-88-0)

Guidance literature:

With phenylsilane; C₁₄H₂₄N₄Si*HI; In benzene-d6; at 60 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1021/acscatal.0c03795

upstream raw materials:

2-Nitroanisole

2-methoxyphenyl isocyanide

formic acid

2-methoxy-phenylamine

Downstream raw materials:

1-(2-methoxy-phenyl)-2-methyl-pyrrolidine

2-methoxy-N-methylaniline

2-methoxyphenyl isocyanide

N,N-bis(2-methoxyphenyl)formamide

Refernces

• 1、 Guo, Luxia,Chen, Zihao,Zhu, Hongmei,Li, Minghao,Gu, Yanlong. "Acid-catalyzed chemodivergent reactions of 2,2-dimethoxyacetaldehyde and anilines". supporting information. p. 1419 - 1422. Retrieved 2020/11/12.
• 2、 Wang, Chenglong,Wu, Licheng,Xu, Wentao,He, Feng,Qu, Jingping,Chen, Yifeng. "Palladium-catalyzed secondary benzylic imidoylative reactions". supporting information. p. 6954 - 6959. Retrieved 2020/09/15.