Propanoic acid, 2-(2-fluorophenoxy)-2-methyl-

Base Information

• Chemical Name: Propanoic acid, 2-(2-fluorophenoxy)-2-methyl-
• CAS No.: 605680-35-1
• Molecular Formula: C10H11FO3
• Molecular Weight: 198.19100
• Mol file: 605680-35-1.mol

Synonyms:PROPANOIC ACID, 2-(2-FLUOROPHENOXY)-2-METHYL-;2-(2-FLUOROPHENOXY)-2-METHYL-PROPANOICACID;

Chemical Property of Propanoic acid, 2-(2-fluorophenoxy)-2-methyl-

Chemical Property:

• PSA: 46.53000
• LogP: 2.06770

Purity/Quality:

97% ^*data from raw suppliers

2-(2-Fluorophenoxy)-2-methylpropanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(2-Fluorophenoxy)-2-methylpropanoic Acid is used as a reactant in the preparation of substituted azoles as hepatitis C virus inhibitors.

Technology Process of Propanoic acid, 2-(2-fluorophenoxy)-2-methyl-

There total 5 articles about Propanoic acid, 2-(2-fluorophenoxy)-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl 2-(2-fluorophenoxy)-2-methylpropanoate → 2-(2-fluorophenoxy)-2-methylpropanoic acid (605680-35-1)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; water;

DOI:10.1021/acs.jmedchem.6b01584

Reference yield:

2-fluorophenol (367-12-4) + 1,1,1-trichloro-2-methyl-2-propanol (57-15-8) → 2-(2-fluorophenoxy)-2-methylpropanoic acid (605680-35-1)

Guidance literature:

2-fluorophenol; 1,1,1-trichloro-2-methyl-2-propanol; With sodium hydroxide; In acetone; for 1h; Heating / reflux;

With hydrogenchloride; In water;

Reference yield:

2-bromo-2-methylpropionic acid (2052-01-9) + 2-fluorophenol (367-12-4) → 2-(2-fluorophenoxy)-2-methylpropanoic acid (605680-35-1)

Guidance literature:

2-fluorophenol; With sodium hydroxide; In butanone; at 50 ℃; for 2h;

2-bromo-2-methylpropionic acid; In butanone; at 50 ℃; for 12h;

DOI:10.1021/ja400659s

upstream raw materials:

2-fluorophenol

1,1,1-trichloro-2-methyl-2-propanol

2-bromo-2-methylpropionic acid

Downstream raw materials:

C₁₀H₁₀ClFO₂